ArticleNature ecology & evolution2021
The functional genetic architecture of egg-laying and live-bearing reproduction in common lizards.
Article in Nature ecology & evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- Comparative Transcriptomic Analyses Identify Candidate Genes for Convergent Reproductive Shifts in a Bimodal Viviparous Amphibian.Molecular ecology · 2026Article
- Genome-Wide Mining of lncRNAs Reveals Their Potential Regulatory Role in the Evolution of Viviparity.Integrative zoology · 2026Article
- Gene Expression and Alternative Splicing Throughout the Reproductive Cycle of a Viviparous Lizard Reveal Novel Genes for Pregnancy and Convergence With Squamates and Mammals.Molecular ecology · 2026Article
- Clinal Variation in Reproductive Modes and Offspring Body Condition Across a Contact Zone of a Bimodal Viviparous Salamander.Ecology and evolution · 2026Article
- The genome sequence of the Eurasian common lizard,Wellcome open research · 2026Article
- Heterochronic changes in gene expression underlie placental evolution in the fish family Poeciliidae.Proceedings. Biological sciences · 2025Article
- Higher locomotor costs of pregnancy in viviparous compared to oviparous common lizards (Ecology and evolution · 2024Article
- Natural variation in theeLife · 2024Article
- Convergent genomic signatures associated with vertebrate viviparity.BMC biology · 2024Article
- Gene expression profile analysis of subregions of the adult female reproductive tract in the brown anole, Anolis sagrei.Reproduction (Cambridge, England) · 2024Article
- Live-bearing cockroach genome reveals convergent evolutionary mechanisms linked to viviparity in insects and beyond.iScience · 2023Article
- Genomic Signatures Associated with Transitions to Viviparity in Cyprinodontiformes.Molecular biology and evolution · 2023Article
- Common lizard microhabitat selection varies by sex, parity mode, and colouration.BMC ecology and evolution · 2023Article
- Genome Evolution and the Future of Phylogenomics of Non-Avian Reptiles.Animals : an open access journal from MDPI · 2023Review
- Comparing the potential for maternal-fetal signalling in oviparous and viviparous lizards.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Understanding the evolution of viviparity using intraspecific variation in reproductive mode and transitional forms of pregnancy.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Ecological and life-history correlates of erythrocyte size and shape in Lepidosauria.Journal of evolutionary biology · 2022Article
- Different Genes are Recruited During Convergent Evolution of Pregnancy and the Placenta.Molecular biology and evolution · 2022Article
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7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All amniotes reproduce either by egg-laying (oviparity), which is ancestral to vertebrates or by live-bearing (viviparity), which has evolved many times independently. However, the genetic basis of these parity modes has never been resolved and, consequently, its convergence across evolutionary scales is currently unknown. Here, we leveraged natural hybridizations between oviparous and viviparous common lizards (Zootoca vivipara) to describe the functional genes and genetic architecture of parity mode and its key traits, eggshell and gestation length, and compared our findings across vertebrates. In these lizards, parity trait genes were associated with progesterone-binding functions and enriched for tissue remodelling and immune system pathways. Viviparity involved more genes and complex gene networks than did oviparity. Angiogenesis, vascular endothelial growth and adrenoreceptor pathways were enriched in the viviparous female reproductive tissue, while pathways for transforming growth factor were enriched in the oviparous. Natural selection on these parity mode genes was evident genome-wide. Our comparison to seven independent origins of viviparity in mammals, squamates and fish showed that genes active in pregnancy were related to immunity, tissue remodelling and blood vessel generation. Therefore, our results suggest that pre-established regulatory networks are repeatedly recruited for viviparity and that these are shared at deep evolutionary scales.
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