ArticleNature medicine2021
Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Nature medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 103 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 1 pooled it
9.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
103 citing papers in PubMed, 1 synthesis or guideline pooled it, 163 citations in OpenAlex.
- Prognostic significance of GATA2 in patients with MDS/AML: a systematic review and meta-analysis.Annals of hematology · 2024Pooled it
- Functional assessment of inherited myeloid neoplasm-associated SAMD9L germline variants via Monoallelic CRISPR modelling.British journal of haematology · 2026Article
- Structural mechanisms of SAMD9 autoinhibition and pathogenic dysregulation.Science advances · 2026Article
- Bone marrow failure syndromes across the age spectrum: diagnostic and therapeutic principles.EClinicalMedicine · 2026Review
- Long-term survival in MIRAGE syndrome: Insights into systemic manifestations and management with review of literature.Endocrine journal · 2026Review
- Clinical characteristics and long-term treatment outcomes in childhood myelodysplastic neoplasm: a nationwide population-based study in Korea.BMC cancer · 2026Article
- From a novel pathogenic SAMD9L variant to cohort-wide insights: Whole-genome sequencing highlights somatic genetic rescue and phenotypic heterogeneity.British journal of haematology · 2026Article
- Decitabine monotherapy for pediatric myelodysplastic syndrome: A case report.Experimental and therapeutic medicine · 2026Article
- Review
- [Clinical characteristics and prognosis of myelodysplastic neoplasms with GATA2 mutations].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2026Article
- High-resolution single-cell mapping of clonal hematopoiesis and structural variation in aplastic anemia.Nature genetics · 2026Article
- Maladaptive somatic gene rescue as predisposition to JAK2 molecular abnormalities? Insights from an Israeli family.Annals of hematology · 2026Article
- Moving Beyond Somatic Alterations: Uncovering the Germline Basis of Myeloid Malignancies.Cancers · 2026Review
- A De Novo Mutation (c.2423A>G) inHuman mutation · 2026Article
- Established and emerging non-cellular therapies in inherited bone marrow failure syndromes.Frontiers in immunology · 2026Review
- PUMA-induced apoptosis drives bone marrow failure and genomic instability in telomerase-deficient mice.Cell death and differentiation · 2026Article
- Evolution of SAMD9 and SAMD9L genes in primates: a complex history of gene loss, gene duplication and pseudogenization.Immunogenetics · 2025Article
- Molecular diagnostics 101: how to use genetic tests in classical hematology.Hematology. American Society of Hematology. Education Program · 2025Review
- SAMD9L inhibits flavivirus translation independently of its capacity to trigger innate immune response.PLoS pathogens · 2025Article
- Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
53 authors at 20 institutions in 21 countries.
Sushree S SahooDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Victor B PastorDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Charnise GoodingsDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Rebecca K VossDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Emilia J KozyraDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-1107-8818
Amina SzvetnikDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Peter NoellkeDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-0281-4732
Michael DworzakDepartment of Pediatrics, St. Anna Children's Hospital and Children's Cancer Research Institute, Medical University of Vienna, Vienna, Austria.
Jan StarýDepartment of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
Franco LocatelliDepartment of Pediatric Hematology and Oncology, IRCCS Ospedale Pediatrico Bambino Gesù, Sapienza University of Rome, Rome, Italy.
Riccardo MasettiPaediatric Oncology and Haematology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Markus SchmuggeDepartment of Hematology and Oncology, University Children's Hospital, Zurich, Switzerland.
Barbara De MoerlooseDepartment of Paediatric Haematology-Oncology, Ghent University Hospital Ghent, Ghent, Belgium.ORCID http://orcid.org/0000-0002-2449-539X
Albert CatalaDepartment of Hematology and Oncology, Hospital Sant Joan de Deu, Barcelona, Spain.
Krisztián KállayDepartment of Pediatric Hematology and Stem Cell Transplantation, Central Hospital of Southern Pest - National Institute of Hematology and Infectious Diseases, Budapest, Hungary.
Dominik TurkiewiczDepartment of Pediatric Oncology/Hematology, Skåne University Hospital, Lund, Sweden.
Henrik HasleDepartment of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-3976-9231
Jochen BuechnerDepartment of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0001-5848-4501
Kirsi JahnukainenDivision of Hematology-Oncology and SCT Children's Hospital, University of Helsinki and Helsinki University Hospital, Hus, Finland.
Marek UssowiczDepartment of Paediatric Bone Marrow Transplantation, Oncology and Hematology, Wroclaw Medical University, Wroclaw, Poland.ORCID http://orcid.org/0000-0001-5725-4835
Sophia PolychronopoulouDepartment of Pediatric Hematology/Oncology, Aghia Sophia Children's Hospital, Athens, Greece.
Owen P SmithDepartment of Pediatric Haematology/Oncology, Children's Health Ireland at Crumlin, Dublin, Ireland.
Oksana FabriDepartment. of Haematology and Transfusiology, National Institute of Children's Diseases Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Shlomit BarzilaiPediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Petah Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Valerie de HaasDutch Childhood Oncology Group, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.
Irith BaumannInstitute of Pathology, Klinikum Kaufbeuren-Ravensburg, Kaufbeuren, Germany.
Stephan Schwarz-FurlanInstitute of Pathology, Klinikum Kaufbeuren-Ravensburg, Kaufbeuren, Germany.
European Working Group of MDS in Children (EWOG-MDS)
Marena R NiewischDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Martin G SauerDepartment of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.
Birgit BurkhardtPediatric Hematology and Oncology, University Hospital Muenster, Muenster, Germany.ORCID http://orcid.org/0000-0002-1151-829X
Peter LangDepartment of Hematology/Oncology and General Pediatrics, Children's University Hospital, University of Tübingen, Tübingen, Germany.
Peter BaderDivision for Stem Cell Transplantation and Immunology, Department for Children and Adolescents, University Hospital Frankfurt, Frankfurt am Main, Germany.
Rita BeierUniversity Hospital Essen, Pediatric Haematology and Oncology, Essen, Germany.
Ingo MüllerDivision of Pediatric Hematology and Oncology, Clinic of Pedatric Hematology and Oncology, University Medical Center of Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-7477-6632
Michael H AlbertDepartment of Pediatrics, Dr. von Hauner Children´s Hospital, University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-9143-3263
Roland MeiselDepartment of Pediatric Oncology, Hematology and Clinical Immunology, Division of Pediatric Stem Cell Therapy, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.
Ansgar SchulzDepartment of Pediatrics, University Medical Center Ulm, Ulm, Germany.ORCID http://orcid.org/0000-0002-7798-7996
Gunnar CarioDepartment of Pediatrics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Pritam K PandaDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-4879-2302
Julius WehrleDepartment of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0001-6514-4230
Shinsuke HirabayashiDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Marta DereckaDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Robert Durruthy-DurruthyMission Bio Inc., South San Francisco, CA, USA.
Gudrun GöhringDepartment of Human Genetics, Hannover Medical School, Hannover, Germany.
Ayami Yoshimi-NoellkeDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Manching KuDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0001-5168-4308
Dirk LebrechtDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Miriam ErlacherDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-7261-1447
Christian FlothoDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Brigitte StrahmDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-6086-130X
Charlotte M NiemeyerDepartment of Pediatrics and Adolescent Medicine, Division of Pediatric Hematology and Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-3856-7937
Marcin W WlodarskiDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA. marcin.wlodarski@stjude.org.ORCID http://orcid.org/0000-0001-6638-9643
University of Freiburg · DECharles University · CZSt. Jude Children's Research Hospital · USChildren's Health Ireland at Crumlin · IEGhent University Hospital · BELjubljana University Medical Centre · SIMedizinische Hochschule Hannover · DEComenius University Bratislava · SKErasmus MC · NLGerman Cancer Research Center · DEGoethe University Frankfurt · DEHeinrich Heine University Düsseldorf · DENárodný ústav detských chorôb · SKNational Centre of Scientific Research "Demokritos" · GRRambam Health Care Campus · ILSemmelweis University · HUUniversität Hamburg · DEUniversity Hospital of Lausanne · CHUniversity of Insubria · ITAarhus University Hospital · DK
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MStem Cell and Transplantation BiologyU54DK106829 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DEREK L STIREWALT · 2015 to 2026
$9.1MNCI NIH HHS P30 CA021765NIDDK NIH HHS U54 DK106829
Abstract
Germline SAMD9 and SAMD9L mutations (SAMD9/9L
Indexed as
AdolescentBone Marrow CellsChildChild, PreschoolClonal EvolutionClonal HematopoiesisFemaleGATA2 Transcription FactorGerm-Line MutationHEK293 CellsHigh-Throughput Nucleotide SequencingHumansInfantIntracellular Signaling Peptides and ProteinsKaplan-Meier EstimateMaleGATA2 protein, humanGATA2 Transcription FactorIntracellular Signaling Peptides and ProteinsSAMD9L protein, humanSAMD9 protein, humanTumor Suppressor Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.