Evidence map›Paper›PMID 34621005›Full record

ArticleCommunications biology2021

Hybrid PET-MRI for early detection of dopaminergic dysfunction and microstructural degradation involved in Parkinson's disease.

Song'an Shang, Daixin Li, Youyong Tian, Rushuai Li, Hongdong Zhao, Liyun Zheng, Yingdong Zhang, Yu-Chen Chen, Xindao Yin

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Song'an Shang *Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Daixin Li *Department of Radiology, Nanjing Second Hospital, Nanjing University of Chinese Medicine, Nanjing, China.
Youyong TianDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Rushuai LiDepartment of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Hongdong ZhaoDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Liyun ZhengCentral Research Institute, United Imaging Healthcare, Shanghai, China.
Yingdong ZhangDepartment of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Yu-Chen ChenDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. chenyuchen1989@126.com.ORCID 0000-0002-8539-7224
Xindao YinDepartment of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. y.163yy@163.com.ORCID 0000-0001-6958-5201
Nanjing Medical University · CNNanjing University of Chinese Medicine · CNUnited Imaging Healthcare (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dopamine depletion and microstructural degradation underlie the neurodegenerative processes in Parkinson's disease (PD). To explore early alterations and underlying associations of dopamine and microstructure in PD patients utilizing the hybrid positron emission tomography (PET)-magnetic resonance imaging (MRI). Twenty-five PD patients in early stages and twenty-four matched healthy controls underwent hybrid

Indexed as

Magnetic Resonance ImagingPositron-Emission TomographyAgedAged, 80 and overDihydroxyphenylalanineDopamineDopaminergic NeuronsFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedParkinson DiseasePutamenSubstantia NigraDihydroxyphenylalanineDopaminefluorodopa F 18

Identifiers

PMID34621005
PMCPMC8497575
OpenAlexW3203832498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.