SynthesisCommunications biology2021
A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
4.5field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Genome-wide analysis implicates inner ear development in Ménière disease.American journal of human genetics · 2026Pooled it
- GWAS meta-analysis reveals key risk loci in essential tremor pathogenesis.Communications biology · 2024Pooled it
- Genome-Wide Association Study of Chronic Dizziness in the Elderly Identifies Loci Implicating MLLT10, BPTF, LINC01224, and ROS1.Journal of the Association for Research in Otolaryngology : JARO · 2023Pooled it
- Association of Bilateral Vestibulopathy With theNeurology. Genetics · 2026Article
- Novel candidate genes for vestibular function identified through GWAS in the hybrid mouse diversity panel.BMC genomics · 2026Article
- The Impact of Genetic Factors in Ménière's Disease.International journal of molecular sciences · 2026Review
- Vestibular Profile of Patients with Hearing Loss Caused by Pathogenic Variants of theOtology & neurotology open · 2026Article
- Inflammation and Oxidative-Stress Pathways Are Associated with Idiopathic Sudden Hearing Loss: A Genome-Wide Association Study in 15,494 Japanese Individuals.International journal of molecular sciences · 2026Article
- Genome-wide analysis implicates inner ear development in Ménière's disease.medRxiv : the preprint server for health sciences · 2026Article
- Tectorial membrane: structure, function, and its implications for hearing loss.Frontiers in neurology · 2025Review
- Knockout ofBiomedicines · 2024Article
- Deciphering the role of FOXP4 in long COVID: exploring genetic associations, evolutionary conservation, and drug identification through bioinformatics analysis.Functional & integrative genomics · 2024Article
- A genome-wide association study identifies novel loci of vertigo in an Asian population-based cohort.Communications biology · 2024Article
- Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease.Nature communications · 2024Article
- The genomic landscape of Ménière's disease: a path to endolymphatic hydrops.BMC genomics · 2024Article
- About the Genetic Contribution to Chronic Dizziness and Episodic Vertigo.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Article
- Identifying the prevalence of clinically actionable drug-gene interactions in a health system biorepository to guide pharmacogenetics implementation services.Clinical and translational science · 2023Article
- HerediGene Population Study IT infrastructure: A model to support genomic research recruitment and precision public health.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2023Article
- The anterior gradient homologue 2 (AGR2) co-localises with the glucose-regulated protein 78 (GRP78) in cancer stem cells, and is critical for the survival and drug resistance of recurrent glioblastoma: in situ and in vitro analyses.Cancer cell international · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 7 institutions in 3 countries.
Astros Th SkuladottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland. astros.skuladottir@decode.is.ORCID 0000-0002-5048-0933
Gyda BjornsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Muhammad Sulaman NawazdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0002-5576-9007
Hannes PetersenFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
Solvi RognvaldssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0002-4376-3361
Kristjan Helgi Swerford MooredeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0002-9579-4362
Pall I OlafssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Sigurður H MagnussondeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0001-6669-3071
Anna BjornsdottirHeilsuklasinn Clinic, Reykjavik, Iceland.
Olafur A SveinssonLandspitali-The National University Hospital of Iceland, Reykjavik, Iceland.
Gudrun R SigurdardottirLaeknasetrid Clinic, Reykjavik, Iceland.
Saedis SaevarsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0001-9392-6184
Erna V IvarsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0002-2069-0681
Lilja StefansdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Bjarni GunnarssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Joseph B MuhlesteinIntermountain Medical Center, Intermountain Heart Institute, Salt Lake City, UT, USA.
Kirk U KnowltonIntermountain Medical Center, Intermountain Heart Institute, Salt Lake City, UT, USA.
David A JonesPrecision Genomics, Intermountain Healthcare, Saint George, UT, USA.
Lincoln D NadauldPrecision Genomics, Intermountain Healthcare, Saint George, UT, USA.
Annette M HartmannDepartment of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Dan RujescuDepartment of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Michael StruppDepartment of Neurology and German Center for Vertigo and Balance Disorders, Ludwig Maximilians University, Munich, Germany.
G Bragi WaltersdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0002-5415-6487
Thorgeir E ThorgeirssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Ingileif JonsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0001-8339-150X
Hilma HolmdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0002-9517-6636
Gudmar ThorleifssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Daniel F GudbjartssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0002-5222-9857
Patrick SulemdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID 0000-0001-7123-6123
Hreinn StefanssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Kari StefanssondeCODE genetics/Amgen Inc., Reykjavik, Iceland. kstefans@decode.is.ORCID 0000-0003-1676-864X
deCODE Genetics (Iceland) · ISIntermountain Healthcare · USMartin Luther University Halle-Wittenberg · DEUniversity of Utah · USGerman Center for Lung Research · DENational University Hospital of Iceland · ISUniversity of Iceland · IS
Funding
Genes for human chronic pain syndromes through whole genome sequencingR01DE022905 · NIDCR · DECODE GENETICS, EHF · PI STEFANSSON, KARI · 2012 to 2016
$2.6MNIDCR NIH HHS R01 DE022905
Abstract
Vertigo is the leading symptom of vestibular disorders and a major risk factor for falls. In a genome-wide association study of vertigo (N
Indexed as
Genome, HumanGenome-Wide Association StudyEar, InnerHumansLabyrinth DiseasesMutation, MissenseVertigo
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.