Evidence map›Paper›PMID 34620951›Full record

ArticleScientific reports2021

Scalable, effective, and rapid decontamination of SARS-CoV-2 contaminated N95 respirators using germicidal ultraviolet C (UVC) irradiation device.

Raveen Rathnasinghe, Robert F Karlicek, Michael Schotsaert, Mattheos Koffas, Brigitte L Arduini, Sonia Jangra, Bowen Wang, Jason L Davis, Mohammed Alnaggar, Anthony Costa and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Disinfection methods against SARS-CoV-2: a systematic review.The Journal of hospital infection · 2022
    Pooled it
  2. Article
  3. Article
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  9. Evaluation of the effectiveness of UV-C dose for photoinactivation of SARS-CoV-2 in contaminated N95 respirator, surgical and cotton fabric masks.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022
    Article
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  18. Approaches towards fighting the COVID‑19 pandemic (Review).International journal of molecular medicine · 2021
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Raveen Rathnasinghe *Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Robert F Karlicek *Smart Lighting Engineering Research Center, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Michael SchotsaertDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Mattheos KoffasDepartment of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Brigitte L ArduiniCenter for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Sonia JangraDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Bowen WangCenter for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Jason L DavisCenter for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Mohammed AlnaggarDepartment of Civil and Environmental Engineering, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Anthony CostaDepartment of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Richard VincentDepartment of Medicine, Section of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Deepak VashishthCenter for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA. vashid@rpi.edu.
Priti BalchandaniBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. priti.balchandani@mssm.edu.
Icahn School of Medicine at Mount Sinai · USRensselaer Polytechnic Institute · US

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
MSHS Translational Science HubUL1TR001433 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WRIGHT, ROSALIND J · 2015 to 2019
$26.6M
Toward a Universal Influenza Virus VaccineP01AI097092 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2012 to 2022
$17.6M
Phase II - Development of a Prophylactic Onchocerciasis Vaccine75N93019C00028 · NIAID · PAI LIFE SCIENCES, INC. · PI CARTER, DARRICK · 2019 to 2019
$3.0M
NCATS NIH HHS UL1 TR001433NCATS NIH HHS UL1 TR004419NIAID NIH HHS 75N93019C00028NIAID NIH HHS HHSN272201400008CNIAID NIH HHS P01 AI097092NIH HHS 5UL1 TR001433
6 · The paper itself

Abstract

Particulate respirators such as N95s are an essential component of personal protective equipment (PPE) for front-line workers. This study describes a rapid and effective UVC irradiation system that would facilitate the safe re-use of N95 respirators and provides supporting information for deploying UVC for decontamination of SARS-CoV-2 during the COVID-19 pandemic. To assess the inactivation potential of the proposed UVC germicidal device as a function of time by using 3 M 8211-N95 particulate respirators inoculated with SARS-CoV-2. A germicidal UVC device to deliver tailored UVC dose was developed and test coupons (2.5 cm

Indexed as

Ultraviolet RaysAnimalsChlorocebus aethiopsCOVID-19DecontaminationEquipment DesignEquipment ReuseHEK293 CellsHumansN95 RespiratorsSARS-CoV-2Time FactorsVero Cells

Identifiers

PMID34620951
PMCPMC8497543
OpenAlexW3204780523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.