ArticleTranslational psychiatry2021
Altered resting-state functional connectome in major depressive disorder: a mega-analysis from the PsyMRI consortium.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.
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Who cites it
75 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- A systematic review of alterations in sensorimotor networks following stroke: implications for integration and functional outcomes across recovery stages.Frontiers in neurology · 2025Pooled it
- Network Centrality and Modularity of Structural Covariance Networks in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study.Brain connectivity · 2023Pooled it
- Modulating salience network connectivity through olfactory nerve stimulation.Translational psychiatry · 2025Trial
- Thalamocortical functional connectivity and rapid antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression.Molecular psychiatry · 2025Trial
- Effects of antipsychotic medication on functional connectivity in major depressive disorder with psychotic features.Molecular psychiatry · 2023Trial
- Stimulation-evoked orbitofrontal activity as a biomarker for DBS personalization in depression.medRxiv : the preprint server for health sciences · 2026Article
- Lag-adjusted functional network connectivity reveals sensorimotor and higher cognitive network alterations in depression.Research square · 2026Article
- Functional alterations of the medial frontal gyrus as candidate biomarkers for resilience in major depressive disorder.BMC psychiatry · 2026Article
- Bridging molecules and connectome: network biomarkers guided by neurotransmitter architecture in major depressive disorder.Translational psychiatry · 2026Article
- The association between spatiotemporal coupling of default mode network and behaviors is specifically modulated by peripheral inflammation in major depressive disorder.BMC psychiatry · 2026Article
- Altered Dynamic Functional Connectivity of the Frontoparietal Network in Major Depressive Disorder: Evidence From a Large-Scale Resting-State fMRI Study.Brain and behavior · 2026Article
- FUNCTIONAL CONNECTIVITY ALTERATIONS IN MAJOR DEPRESSIVE DISORDER.bioRxiv : the preprint server for biology · 2026Article
- Comparing local brain activity and distant functional connectivity in transgender women compared to cisgender controls.Scientific reports · 2026Article
- Complex Neurobiological Mechanisms and Risk Factors Underlying Late-Life Depression.Advances in experimental medicine and biology · 2026Review
- Brain entropy as a biomarker of major depression in adolescents and young adults: insights from multimodal resting-state functional magentic resonance imaging.Psychoradiology · 2026Article
- Machine learning combined with resting-state functional MRI to characterize functional brain differences in post-stroke depression.Frontiers in psychiatry · 2026Article
- Failure to integrate: Connector hub dysfunction in major depressive disorder.NeuroImage. Clinical · 2026Article
- The neuroimaging correlates of depression established across six large-scale population datasets.Nature. Mental health · 2026Article
- Treatment response to bupropion: an investigation of changes in resting-state functional connectivity in patients with major depressive disorder.Psychopharmacology · 2025Article
- Associations Between Left DLPFC iTBS-induced Functional Connectivity Changes and Depressive Symptoms: An Exploratory Study.Actas espanolas de psiquiatria · 2025Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
32 authors at 20 institutions in 7 countries.
Funding
Abstract
Major depressive disorder (MDD) is associated with abnormal neural circuitry. It can be measured by assessing functional connectivity (FC) at resting-state functional MRI, that may help identifying neural markers of MDD and provide further efficient diagnosis and monitor treatment outcomes. The main aim of the present study is to investigate, in an unbiased way, functional alterations in patients with MDD using a large multi-center dataset from the PsyMRI consortium including 1546 participants from 19 centers ( www.psymri.com ). After applying strict exclusion criteria, the final sample consisted of 606 MDD patients (age: 35.8 ± 11.9 y.o.; females: 60.7%) and 476 healthy participants (age: 33.3 ± 11.0 y.o.; females: 56.7%). We found significant relative hypoconnectivity within somatosensory motor (SMN), salience (SN) networks and between SMN, SN, dorsal attention (DAN), and visual (VN) networks in MDD patients. No significant differences were detected within the default mode (DMN) and frontoparietal networks (FPN). In addition, alterations in network organization were observed in terms of significantly lower network segregation of SMN in MDD patients. Although medicated patients showed significantly lower FC within DMN, FPN, and SN than unmedicated patients, there were no differences between medicated and unmedicated groups in terms of network organization in SMN. We conclude that the network organization of cortical networks, involved in processing of sensory information, might be a more stable neuroimaging marker for MDD than previously assumed alterations in higher-order neural networks like DMN and FPN.
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