ReviewCurrent opinion in cardiology2021
Evaluation of coronary stenosis versus plaque burden for atherosclerotic cardiovascular disease risk assessment and management.
Review in Current opinion in cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 17 citations in OpenAlex.
- Deep Learning Optimizes the Diagnostic Performance of Coronary Computed Tomography Angiography in Heavily Calcified Coronary Plaques: A Chinese Multicenter Study.Reviews in cardiovascular medicine · 2026Article
- Time-dependent prognostic value of coronary plaque burden and hyperemic myocardial blood flow.European journal of nuclear medicine and molecular imaging · 2026Article
- Clinically Validated XAI for Calcified Plaque Segmentation in Coronary CT Angiography.Journal of clinical medicine · 2026Article
- Cardiovascular event rate modifies response to pharmacologic LDL-C lowering in primary prevention: implications of a systematic review and meta-analysis for clinical practice.American journal of preventive cardiology · 2026Article
- Prognostic value of preoperative CT-derived fractional flow reserve after transcatheter or surgical aortic valve replacement in patients with severe aortic stenosis.BMC medical imaging · 2026Observational
- Brain‑heart axis: Neurostimulation techniques in ischemic heart disease (Review).International journal of molecular medicine · 2025Review
- Association Between HNP1-3 and Atherosclerotic Plaque Burden in Subclinical Atherosclerosis and the Mediating Effect of PCSK9.Clinical and translational science · 2025Article
- Assessment of Cervicocephalic-Peripheral Atherosclerotic Burden Improves Prognostic Stratification in Patients with Ischemic Cerebrovascular Disease.Journal of clinical medicine · 2025Article
- Bibliometric analysis of CT-based atherosclerosis plaque imaging in coronary artery disease: from "gatekeeper" of invasive angiography to "whistleblower" of high-risk patients.Quantitative imaging in medicine and surgery · 2025Article
- Pericoronary adipose tissue attenuation on coronary computed tomography angiography: Possibilities and challenges.Atherosclerosis · 2025Article
- Effect of rapamycin-eluting stents on in-stent restenosis and early inflammatory response in coronary artery narrowing animal models.Journal of cardiothoracic surgery · 2025Article
- Comprehensive Risk Assessment of LAD Disease Progression in CCTA: The CLAP Score Study.Journal of cardiovascular development and disease · 2024Article
- Left Main Coronary Artery Calcium and Diabetes Confer Very-High-Risk Equivalence in Coronary Artery Calcium >1,000.JACC. Cardiovascular imaging · 2024Article
- Carotid Ultrasound-Based Plaque Score for the Allocation of Aspirin for the Primary Prevention of Cardiovascular Disease Events: The Multi-Ethnic Study of Atherosclerosis and the Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2024Article
- Lumbar disc herniation is an independent predictor of plaque burden in the patients with unstable angina.Frontiers in cardiovascular medicine · 2024Article
- Advanced subclinical atherosclerosis: A novel category within the cardiovascular risk continuum with distinct treatment implications.American journal of preventive cardiology · 2023Article
- Correlation of Computed Tomographic Angiography in Patients Undergoing Coronary Artery Bypass Grafting and Effect of Standardized Rehabilitation Nursing.Computational intelligence and neuroscience · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
purpose of reviewTo provide a summary of recent literature on the relative impact of luminal stenosis versus atherosclerotic plaque burden in atherosclerotic cardiovascular disease (ASCVD) risk stratification and management. RECENT
findingsRecent results from both randomized controlled clinical trials as well as observational cohort studies have demonstrated that ASCVD risk is mediated mainly by the extent of atherosclerotic disease burden rather than by the presence of coronary stenosis or inducible ischemia. Although patients with obstructive CAD are generally at higher risk for ASCVD events than patients with nonobstructive CAD, this is driven by a higher plaque burden in those with obstructive CAD. Accordingly, the ASCVD risk for a given plaque burden is similar in patients with and without obstructive CAD. Accompanying these observations are randomized controlled trial data, which show that optimization of medical therapy instead of early revascularization is most important for improving prognosis in patients with stable obstructive CAD. SUMMARY: Emerging evidence shows that atherosclerotic plaque burden, and not stenosis per se, is the main driver of ASCVD risk in patients with CAD. This information challenges the current paradigm of selecting patients for intensive secondary prevention measures based primarily on the presence of obstructive CAD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.