Evidence map›Paper›PMID 34620728›Full record

ArticlePediatrics2021

COVID-19-Associated Orphanhood and Caregiver Death in the United States.

Susan D Hillis, Alexandra Blenkinsop, Andrés Villaveces, Francis B Annor, Leandris Liburd, Greta M Massetti, Zewditu Demissie, James A Mercy, Charles A Nelson Iii, Lucie Cluver and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
79.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 232 citations in OpenAlex.

  1. Trial
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  5. American Indian Adolescent Perspectives on COVID-19 Impacts Within Great Plains Area Reservations.Journal of transcultural nursing : official journal of the Transcultural Nursing Society · 2025
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  12. Accelerating achievement for Africa's adolescents.Contemporary social science · 2025
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  15. Review
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Susan D HillisCenters for Disease Control and Prevention, Atlanta, Georgia.
Alexandra BlenkinsopDepartment of Mathematics.
Andrés VillavecesCenters for Disease Control and Prevention, Atlanta, Georgia.
Francis B AnnorCenters for Disease Control and Prevention, Atlanta, Georgia.
Leandris LiburdCenters for Disease Control and Prevention, Atlanta, Georgia.
Greta M MassettiCenters for Disease Control and Prevention, Atlanta, Georgia.
Zewditu DemissieCenters for Disease Control and Prevention, Atlanta, Georgia.
James A MercyCenters for Disease Control and Prevention, Atlanta, Georgia.
Charles A Nelson IiiDepartment of Pediatrics, Harvard Medical School, Harvard Graduate School of Education, Harvard University and Boston Children's Hospital, Cambridge, Massachusetts.
Lucie CluverDepartments of Social Policy and Intervention.
Seth FlaxmanDepartment of Mathematics.
Lorraine SherrInstitute for Global Health, University College London, London, United Kingdom.
Christl A DonnellyMedical Research Council (MRC) Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom.
Oliver RatmannDepartment of Mathematics.
H Juliette T UnwinMedical Research Council (MRC) Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom.
Centers for Disease Control and Prevention · USHarvard University · USImperial College London · GBMedical Research Council · GBUniversity College London · GBUniversity of Cape Town · ZA

Funding

4/5 The Cumulative Risk of Substance Exposure and Early Life Adversity on Child Health Development and Outcomes (Administrative Supplement)R34DA050289 · NIDA · BOSTON CHILDREN'S HOSPITAL · PI NELSON, CHARLES ALEXANDER · 2019 to 2021
$988k
Intramural CDC HHS CC999999Medical Research Council MC_PC_19012Medical Research Council MR/R015600/1NIDA NIH HHS R34 DA050289
6 · The paper itself

Abstract

backgroundMost coronavirus disease 2019 (COVID-19) deaths occur among adults, not children, and attention has focused on mitigating COVID-19 burden among adults. However, a tragic consequence of adult deaths is that high numbers of children might lose their parents and caregivers to COVID-19-associated deaths.

methodsWe quantified COVID-19-associated caregiver loss and orphanhood in the United States and for each state using fertility and excess and COVID-19 mortality data. We assessed burden and rates of COVID-19-associated orphanhood and deaths of custodial and coresiding grandparents, overall and by race and ethnicity. We further examined variations in COVID-19-associated orphanhood by race and ethnicity for each state.

resultsWe found that from April 1, 2020, through June 30, 2021, >140 000 children in the United States experienced the death of a parent or grandparent caregiver. The risk of such loss was 1.1 to 4.5 times higher among children of racial and ethnic minority groups compared with non-Hispanic White children. The highest burden of COVID-19-associated death of parents and caregivers occurred in Southern border states for Hispanic children, in Southeastern states for Black children, and in states with tribal areas for American Indian and/or Alaska Native populations.

conclusionsWe found substantial disparities in distributions of COVID-19-associated death of parents and caregivers across racial and ethnic groups. Children losing caregivers to COVID-19 need care and safe, stable, and nurturing families with economic support, quality child care, and evidence-based parenting support programs. There is an urgent need to mount an evidence-based comprehensive response focused on those children at greatest risk in the states most affected.

Identifiers

PMID34620728
PMCPMC10896160
OpenAlexW3198960517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.