Evidence map›Paper›PMID 34620663›Full record

ArticleBMJ open2021

Women's acceptability of and experience with primary human papillomavirus testing for cervix screening: HPV FOCAL trial cross-sectional online survey results.

Laurie W Smith, C Sarai Racey, Lovedeep Gondara, Mel Krajden, Marette Lee, Ruth Elwood Martin, Gavin Stuart, Stuart Peacock, Andrew J Coldman, Eduardo L Franco and 2 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00461760 (A Randomized Controlled Evaluation of HPV Testing for Cervical Cancer Screening), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00461760 nacompletednot on this map

A Randomized Controlled Evaluation of HPV Testing for Cervical Cancer Screening

TypeinterventionalSponsorUniversity of British ColumbiaRan2007 to 2018Enrolled25,223ConditionsCervical Cancer ScreeningArmsCervical cancer screening undertaken by HPV testing as a single primary screening test with cytology triage of women who are HPV positive
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Laurie W SmithDepartment of Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada laurie.smith@bccancer.bc.ca.ORCID 0000-0002-9463-1713
C Sarai RaceyWomen's Health Research Institute, BC Women's Hospital and Health Centre, Vancouver, British Columbia, Canada.
Lovedeep GondaraDepartment of Data and Analytics, BC Cancer Agency, Vancouver, British Columbia, Canada.
Mel KrajdenFaculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
Marette LeeFaculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
Ruth Elwood MartinFaculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
Gavin StuartFaculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
Stuart PeacockDepartment of Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada.
Andrew J ColdmanDepartment of Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada.
Eduardo L FrancoDepartment of Oncology, McGill University, Montreal, Québec, Canada.ORCID 0000-0002-4409-8084
Dirk van NiekerkFaculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
Gina S OgilvieWomen's Health Research Institute, BC Women's Hospital and Health Centre, Vancouver, British Columbia, Canada.ORCID 0000-0001-5783-4493
BC Cancer Agency · CAUniversity of British Columbia · CAMcGill University · CA

Funding

CIHR MCT-82072
6 · The paper itself

Abstract

objectiveTo study participant's acceptability of and attitudes towards human papillomavirus (HPV) testing compared with cytology for cervical cancer screening and what impact having an HPV positive result may have in future acceptability of screening.

designCross-sectional online survey of clinical trial participants.

settingPrimary care, population-based Cervix Screening Program, British Columbia, Canada.

participantsA total of 5532 participants from the HPV FOCAL trial, in which women received HPV and cytology testing at study exit, were included in the analysis. Median age was 54 years. The median time of survey completion was 3 years after trial exit. OUTCOME MEASURES: Acceptability of HPV testing for primary cervical cancer screening (primary); attitudes and patient perceptions towards HPV testing and receipt of HPV positive screen results (secondary).

resultsMost respondents (63%) were accepting of HPV testing, with the majority (69%) accepting screening to begin at age 30 years with HPV testing. Only half of participants (54%) were accepting of an extended screening interval of 4-5 years. In multivariable logistic regression, women who received an HPV positive screen test result during the trial (OR=1.41 95% CI 1.11 to 1.80) or were older (OR=1.01, 95% CI 1.00 to 1.02) were more likely to report HPV testing as acceptable.

conclusionsIn this evaluation of acceptability and attitudes regarding HPV testing for cervix screening, most are accepting of HPV testing for screening; however, findings indicate heterogeneity in concerns and experiences surrounding HPV testing and receipt of HPV positive results. These findings provide insights for the development of education, information and communication strategies during implementation of HPV-based cervical cancer screening. TRIAL REGISTRATION NUMBERS: ISRCTN79347302 and NCT00461760.

Indexed as

AlphapapillomavirusPapillomavirus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsAdultBritish ColumbiaCross-Sectional StudiesEarly Detection of CancerFemaleHumansMass ScreeningMiddle AgedPapillomaviridaeVaginal Smearsgynaecological oncologyhealth policypreventive medicinepublic health

Identifiers

PMID34620663
PMCPMC8499254
OpenAlexW3204275400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.