ArticleDiabetes2021
Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes.
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Article in Diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
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26 citing papers in PubMed, 27 citations in OpenAlex.
- Immune dysregulation and stem-like CD8+ T cell enrichment in type 1 diabetes pancreatic lymph nodes.The Journal of clinical investigation · 2026Article
- The Gut-Pancreas Axis in Type 1 Diabetes: Emerging Insights into Microbiota and Immune Interactions.International journal of molecular sciences · 2026Review
- Aberrant immune regulation and enrichment of stem-like CD8bioRxiv : the preprint server for biology · 2026Article
- Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes.Cell reports · 2026Article
- Synthetic Immunological Niche Reveals Early Immune Dysregulation and Stratifies Therapeutic Response in Type 1 Diabetes.bioRxiv : the preprint server for biology · 2026Article
- Artificial intelligence-driven therapeutics for disease modification in type 1 diabetes: a digital public health and clinical translation framework.Frontiers in public health · 2026Review
- Type 1 Diabetes Depends on CD4-Driven Expression of the Transcriptional Repressor Bcl6.Diabetes · 2025Article
- Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset.Nature communications · 2025Article
- Characterizing cell-type spatial relationships across length scales in spatially resolved omics data.Nature communications · 2025Article
- Platelets as a potential new immune coordinator in T cell-mediated aplastic anemia.Frontiers in oncology · 2025Review
- CXCR5 engineered human and murine Tregs for targeted suppression in secondary and tertiary lymphoid organs.Frontiers in immunology · 2025Article
- Cross-tissue transcriptome-wide association identify novel T1D susceptibility genes and drug candidates.Frontiers in immunology · 2025Article
- Lymph nodes as gatekeepers of autoimmune diseases.RMD open · 2024Review
- Characterizing cell-type spatial relationships across length scales in spatially resolved omics data.bioRxiv : the preprint server for biology · 2024Article
- Advances in non-viral mRNA delivery to the spleen.Biomaterials science · 2024Review
- The immunology of type 1 diabetes.Nature reviews. Immunology · 2024Review
- Mechanisms underlying the development of type 1 diabetes in ART-treated people living with HIV: an enigmatic puzzle.Frontiers in immunology · 2024Review
- Human immune phenotyping reveals accelerated aging in type 1 diabetes.JCI insight · 2023Article
- The pathogenic "symphony" in type 1 diabetes: A disorder of the immune system, β cells, and exocrine pancreas.Cell metabolism · 2023Review
- Pancreatic draining lymph nodes (PLNs) serve as a pathogenic hub contributing to the development of type 1 diabetes.Cell & bioscience · 2023Review
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Authors and funding
28 authors at 4 institutions in 2 countries.
Andrea VecchioneDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Tatiana JofraDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Jolanda GerosaDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Kimberly ShankwitzTissue Analysis Core, Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Roberta Di FonteDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Giuseppe GalvaniDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Elio IppolitoDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Maria Pia CicaleseSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Andrew R SchultzDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida Diabetes Institute, Gainesville, FL.
Howie R SeayDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida Diabetes Institute, Gainesville, FL.
Mariagrazia FavellatoDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Giulia MilardiDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Angela StabiliniDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Francesca RagognaDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Pauline GroganDepartment of Internal Medicine, IRCCS San Raffaele Hospital, Milan, Italy.
Eleonora BianconiDepartment of Internal Medicine, IRCCS San Raffaele Hospital, Milan, Italy.
Andrea LaurenziDepartment of Internal Medicine, IRCCS San Raffaele Hospital, Milan, Italy.
Amelia CarettoDepartment of Internal Medicine, IRCCS San Raffaele Hospital, Milan, Italy.
Rita NanoDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Raffaela MelziDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Nichole DanzlColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.
Emanuele BosiDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Lorenzo PiemontiDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Alessandro AiutiSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Todd BruskoDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida Diabetes Institute, Gainesville, FL.
Constantinos PetrovasTissue Analysis Core, Immunology Laboratory, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Manuela BattagliaDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Georgia FousteriDiabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy fousteri.georgia@hsr.it.ORCID 0000-0001-7745-7517
Vita-Salute San Raffaele University · ITUniversity of Florida · USNational Institutes of Health · USColumbia University Irving Medical Center · US
Funding
Project 3P01AI042288 · NIAID · UNIVERSITY OF FLORIDA · PI Todd Michael Brusko · 1997 to 2026
$32.9MNorthwest Clinical Center for Type 1 Diabetes - TrialNetU01DK061034 · NIDDK · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI GREENBAUM, CARLA J · 2001 to 2018
$10.3MType I Diabetes Trialnet at StsnfordU01DK061042 · NIDDK · STANFORD UNIVERSITY · PI WILSON, DARRELL M · 2001 to 2018
$8.5MUCSF Trialnet: A Phase II Trial of Imatimib in New Onset Type I DiabetesU01DK061010 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GITELMAN, STEPHEN E · 2001 to 2018
$8.1MType 1 Diabetes-A Proposal for Prevention & InterventionU01DK085476 · NIDDK · UNIVERSITY OF MINNESOTA · PI MORAN, ANTOINETTE M. · 2009 to 2018
$7.1MPrediction and Prevention of Type I DiabetesU01DK061058 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKER, DOROTHY J · 2001 to 2018
$6.5MTrialNet: University of Florida Clinical Center and NetworkU01DK085461 · NIDDK · UNIVERSITY OF FLORIDA · PI HALLER, MICHAEL JAMES · 2009 to 2018
$5.9MTrialNet: Diabetes Type 1 PreventionU01DK085509 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI GOTTLIEB, PETER A · 2009 to 2018
$5.8MType 1 Diabetes TrialNet Clinical Center: Effects of Alefacept in New Onset T1DU01DK085499 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BAIDAL, DAVID · 2009 to 2018
$4.9MVanderbilt University: Clinical Center Application, Type 1 Diabetes TrialNetU01DK085465 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RUSSELL, WILLIAM E · 2009 to 2018
$4.8MType 1 Diabetes TrialNet: Clinical Center at Yale University (U01)U01DK085466 · NIDDK · YALE UNIVERSITY · PI HEROLD, KEVAN C · 2009 to 2018
$3.3MType 1 Diabetes TrialNet at Indiana University Clinical CenterU01DK085505 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI DIMEGLIO, LINDA A · 2009 to 2013
$3.0MNIAID NIH HHS P01 AI042288NIDDK NIH HHS U01 DK061010NIDDK NIH HHS U01 DK061034NIDDK NIH HHS U01 DK061042NIDDK NIH HHS U01 DK061058NIDDK NIH HHS U01 DK085453NIDDK NIH HHS U01 DK085461NIDDK NIH HHS U01 DK085463NIDDK NIH HHS U01 DK085465NIDDK NIH HHS U01 DK085466NIDDK NIH HHS U01 DK085476NIDDK NIH HHS U01 DK085499NIDDK NIH HHS U01 DK085504NIDDK NIH HHS U01 DK085505NIDDK NIH HHS U01 DK085509NIDDK NIH HHS U01 DK103153NIDDK NIH HHS U01 DK103180NIDDK NIH HHS U01 DK103266
Abstract
In the attempt to understand the origin of autoantibody (AAb) production in patients with and at risk for type 1 diabetes (T1D), multiple studies have analyzed and reported alterations in T follicular helper (Tfh) cells in presymptomatic AAb
Indexed as
AdultAnimalsCase-Control StudiesCells, CulturedDiabetes Mellitus, Type 1HumansLymph NodesLymphocyte CountMiceMice, Inbred C57BLMice, Inbred NODMice, SCIDPancreasSpleenT-Lymphocytes, Regulatory
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.