Evidence map›Paper›PMID 34620596›Full record

ArticleBJGP open2021

Excessive polypharmacy and potentially inappropriate prescribing in 147 care homes: a cross-sectional study.

Clare MacRae, David Ag Henderson, Stewart W Mercer, Jenni Burton, Nicosha De Souza, Paula Grill, Charis Marwick, Bruce Guthrie

Open access · goldAbstract read
In one paragraph

Article in BJGP open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Clare MacRaeCentre for Population Health Sciences, Usher Institute, University of Edinburgh, Edinburgh, UK.
David Ag HendersonCentre for Population Health Sciences, Usher Institute, University of Edinburgh, Edinburgh, UK David.Henderson@ed.ac.uk.
Stewart W MercerCentre for Population Health Sciences, Usher Institute, University of Edinburgh, Edinburgh, UK.
Jenni BurtonInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Nicosha De SouzaPopulation Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.
Paula GrillPopulation Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.
Charis MarwickPopulation Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.
Bruce GuthrieCentre for Population Health Sciences, Usher Institute, University of Edinburgh, Edinburgh, UK.
University of Edinburgh · GBUniversity of Dundee · GBGenomics (United Kingdom) · GBUniversity of Glasgow · GB

Funding

Chief Scientist Office PCL/21/01
6 · The paper itself

Abstract

backgroundCare home residents often have multiple cognitive and physical impairments, and are at high risk of adverse drug events (ADEs).

aimTo describe excessive polypharmacy and potentially inappropriate prescribing predisposing care home residents to ADEs. DESIGN &

settingA cross-sectional analysis of all dispensed prescriptions for 147 care home residents in Tayside and Fife, Scotland.

methodPrevalence of excessive polypharmacy was examined using multilevel logistic regression, by modelling associations between individual and care home predictors with excessive polypharmacy (≥10 drugs). Prescribing of drugs known to increase the risk of eight clinically important ADE categories was examined. Drugs prescribed within each ADE category, for each resident, were counted.

resultsIn total, 32.3% (

conclusionExcessive polypharmacy is common in care home residents and is associated with both individual and care home predictors. Potentially inappropriate prescribing of drugs that predisposed residents to all included ADE categories is common. Research is needed to support and evaluate safe care home prescribing practices.

Indexed as

care homesdrug-related side effects and adverse reactionsgeneral practiceolder peoplepolypharmacyprescribing safety

Identifiers

PMID34620596
PMCPMC9447292
OpenAlexW3202585533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.