Evidence map›Paper›PMID 34620363›Full record

ArticleClinical nutrition ESPEN2021

Protein provision and lower mortality in critically ill patients with COVID-19.

Jose Henrique Silvah, Cristiane Maria Martires de Lima, Carolina Ferreira Nicoletti, Ana Carolina Barbosa, Gizela Pedroso Junqueira, Selma Freire de Carvalho da Cunha, Julio Sergio Marchini

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Article in Clinical nutrition ESPEN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jose Henrique SilvahDivision of Medical Nutrition, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil; ATN - Alimentar Terapia Nutricional, Coordination and Assistance in Nutritional Therapy, Ribeirão Preto, SP, Brazil. Electronic address: jhdasilvah@gmail.com.
Cristiane Maria Martires de LimaDivision of Medical Nutrition, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil; ATN - Alimentar Terapia Nutricional, Coordination and Assistance in Nutritional Therapy, Ribeirão Preto, SP, Brazil.
Carolina Ferreira NicolettiDepartament of Health Science, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Ana Carolina BarbosaATN - Alimentar Terapia Nutricional, Coordination and Assistance in Nutritional Therapy, Ribeirão Preto, SP, Brazil.
Gizela Pedroso JunqueiraDivision of Medical Nutrition, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Selma Freire de Carvalho da CunhaDivision of Medical Nutrition, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Julio Sergio MarchiniDivision of Medical Nutrition, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severely impacted the management of critically ill patients, including nutritional therapy. This study aimed to verify an association between mortality and the energy and protein provided to critically ill patients affected by the SARS-CoV-2 and receiving enteral nutrition support.

methodsPatients with confirmed COVID-19, with >7 days of stay in the ICU, on enteral nutrition were followed from the moment of hospitalization until discharge from the ICU or death. Data about age, gender, Simplified Acute Physiology Score III (SAPS3), intensive care unit (ICU) length of stay, days on mechanical ventilation (MV), clinical endpoint outcome (discharge or death), and daily energy and protein provision were collected from electronic medical records. Cox regression analyses and Kaplan-Meyer curves were used in statistical analysis.

resultsFifty-two patients (66.2 ± 13.1 years; 53.8% women) were enrolled in the present study. The mean length of hospitalizations and SAPS3 score were 17.8 ± 9.8 days and 78.7 ± 14.7, respectively; all patients needed mechanical ventilation (mean of days was 16.42 ± 9.1). For most patients (73.1%) the endpoint was death. Twenty-five percent of patients had protein supply >0.8 g/IBW/day. Survival during COVID-19 hospitalization at ICU was significantly different among patients according to protein supply (p = 0.005). Hazard Ratios (HR) for protein supply showed that a protein intake >0.8 g/IBW/day was associated with significantly lower mortality (HR 0.322, p = 0.049).

conclusionOur study suggests that a protein supply at least > 0.8 g/IBW/day could be related to reduced mortality in ICU patients with COVID-19.

Indexed as

COVID-19Critical IllnessEnteral NutritionFemaleHumansIntensive Care UnitsMaleSARS-CoV-2COVID-19Critical careMortalityNutritional therapyProtein supplyTube feeding

Identifiers

PMID34620363
PMCPMC8282450

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.