Evidence map›Paper›PMID 34620168›Full record

ArticleRespiratory research2021

Prostaglandin D

Saskia Carstensen, Christina Gress, Veit J Erpenbeck, Shamsah D Kazani, Jens M Hohlfeld, David A Sandham, Meike Müller

Open access · goldAbstract readComparative Study
In one paragraph

Article in Respiratory research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Mechanisms and therapeutic strategies of asthma: from bench to bedside.Signal transduction and targeted therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Saskia Carstensen *Department of Biomarker Analysis and Development, Clinical Airway Research, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany.
Christina Gress *Department of Biomarker Analysis and Development, Clinical Airway Research, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany.
Veit J ErpenbeckNovartis Pharma AG, Basel, Switzerland.
Shamsah D KazaniNovartis Institutes for Biomedical Research, Cambridge, MA, USA.
Jens M HohlfeldDepartment of Biomarker Analysis and Development, Clinical Airway Research, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany.
David A SandhamNovartis Institutes for Biomedical Research, Cambridge, MA, USA.
Meike MüllerDepartment of Biomarker Analysis and Development, Clinical Airway Research, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany. meike.mueller@item.fraunhofer.de.ORCID http://orcid.org/0000-0002-7586-356X
Fraunhofer Institute for Toxicology and Experimental Medicine · DENovartis (United States) · USMedizinische Hochschule Hannover · DENovartis (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProstaglandin D

methodsEosinophils and ILC2s were isolated from peripheral blood of atopic asthmatic patients. Eosinophil shape change, ILC2 migration and IL-5/IL-13 cytokine secretion were measured after stimulation with seven PGD

resultsSelected metabolites induced eosinophil shape change with similar nanomolar potencies except for 9α,11β-PGF

conclusionProstaglandin D

Indexed as

AdolescentAdultAgedAsthmaCell MovementCells, CulturedCell ShapeEosinophilsFemaleHumansIndoleacetic AcidsInterleukin-13Interleukin-5LymphocytesMaleMiddle AgedfevipiprantIL13 protein, humanIL5 protein, humanIndoleacetic AcidsInterleukin-13Interleukin-5Prostaglandin AntagonistsProstaglandin D2prostaglandin D2 receptorPyridinesReceptors, ImmunologicReceptors, Prostaglandin13,14-Dihydro-15-keto-PGD2AsthmaCRTH2DP2Eosinophil shape changeFevipiprantPGD2PGD2 metabolitesType 2 innate lymphocyte cells

Identifiers

PMID34620168
PMCPMC8499518
OpenAlexW3202546326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.