Evidence map›Paper›PMID 34620004›Full record

ArticleCancer control : journal of the Moffitt Cancer Center

Durable Progression-Free Survival With the Use of BRAF and MEK Inhibitors in Four Cases With

Michael J Fusco, Yolanda Piña, Robert J Macaulay, Solmaz Sahebjam, Peter A Forsyth, Edwin Peguero, Christine M Walko

Open access · goldAbstract readCase Reports
In one paragraph

Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Ganglioglioma and gangliocytoma: a review for pathologists.Journal of pathology and translational medicine · 2026
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  15. Case report:Frontiers in medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Michael J FuscoDepartment of Individualized Cancer Medicine, 25301Moffitt Cancer Center, Tampa, FL, USA.ORCID https://orcid.org/0000-0002-5883-7466
Yolanda PiñaDepartment of Neuro-Oncology, 25301Moffitt Cancer Center, Tampa, FL, USA.ORCID https://orcid.org/0000-0003-1383-5704
Robert J MacaulayDepartment of Neuro-Oncology, 25301Moffitt Cancer Center, Tampa, FL, USA.
Solmaz SahebjamDepartment of Neuro-Oncology, 25301Moffitt Cancer Center, Tampa, FL, USA.
Peter A ForsythDepartment of Neuro-Oncology, 25301Moffitt Cancer Center, Tampa, FL, USA.
Edwin PegueroDepartment of Neuro-Oncology, 25301Moffitt Cancer Center, Tampa, FL, USA.
Christine M WalkoDepartment of Individualized Cancer Medicine, 25301Moffitt Cancer Center, Tampa, FL, USA.
Moffitt Cancer Center · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
NCI NIH HHS P30 CA076292
6 · The paper itself

Abstract

introductionCASE SERIES: We describe four patients with

conclusionCombination of BRAF/MEK inhibition can be a novel, promising approach as targeted therapy in gliomas with

Indexed as

AdultBrain NeoplasmsFemaleGliomaHumansMaleMitogen-Activated Protein KinasesNeoplasm GradingProgression-Free SurvivalProto-Oncogene Proteins B-rafYoung AdultMitogen-Activated Protein KinasesProto-Oncogene Proteins B-rafBRAFbrain tumorcancerCNS tumorglioblastomatreatment

Identifiers

PMID34620004
PMCPMC8506147
OpenAlexW3201691268

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.