Evidence map›Paper›PMID 34619994›Full record

ArticleInternational journal of immunopathology and pharmacology

Lymphocyte subsets as a predictor of severity and prognosis in COVID-19 patients.

Peng Zhang, Wei Du, Ting Yang, Lei Zhao, Richeng Xiong, Yongqiang Li, Yan Geng, Weizhong Lu, Juan Zhou

Open access · goldAbstract read
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

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  6. Angiotensin-(1-7) decreases inflammation and lung damage caused by betacoronavirus infection in mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Peng ZhangDepartment of Hematology, General Hospital of Southern Theater Command, Guangzhou, China.ORCID https://orcid.org/0000-0001-7626-1977
Wei DuDepartment of Infectious Disease, Huoshenshan Hospital, Wuhan, China.
Ting YangDepartment of Infectious Disease, Huoshenshan Hospital, Wuhan, China.
Lei ZhaoDepartment of Infectious Disease, Huoshenshan Hospital, Wuhan, China.
Richeng XiongDepartment of Infectious Disease, Huoshenshan Hospital, Wuhan, China.
Yongqiang LiDepartment of Infectious Disease, Huoshenshan Hospital, Wuhan, China.
Yan GengDepartment of Infectious Disease, Huoshenshan Hospital, Wuhan, China.
Weizhong LuDepartment of Infectious Disease, Huoshenshan Hospital, Wuhan, China.
Juan ZhouDepartment of Infectious Disease, Huoshenshan Hospital, Wuhan, China.
General Hospital of Guangzhou Military Command · CN81th Hospital of PLA · CN303 Hospital of People's Liberation Army · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronavirus disease 2019 (COVID-19) had become a worldwide health threat. Early prediction of the severity of COVID-19 patients was important for reducing death rate and controlling this disease. METHODS AND MATERIALS: A total of 301 patients confirmed with COVID-19 in Wuhan from 8 February to 10 April 2020 were included. Clinical data were collected and analyzed. Diagnostic and prognostic utility of blood cell counts and lymphocyte subsets in COVID-19 patients were investigated. The receiver operator characteristic curve (ROC) was used in discriminating the mild and severe/critical cases.

resultsThere were difference in blood cell counts and lymphocyte subsets among mild, severe and critical patients, which were also influenced by comorbidities and duration of disease. The area under the ROC of lymphocyte, CD3

conclusionBlood cell counts and lymphocyte subsets correlated with severity of COVID-19.

Indexed as

AdultAgedAged, 80 and overCD4 Lymphocyte CountChinaCOVID-19FemaleHospital MortalityHost-Pathogen InteractionsHumansLymphocyte SubsetsMaleMiddle AgedPhenotypePredictive Value of TestsPrognosisCOVID-19lymphocyte subsetsprognosisrisk factorsseverity

Identifiers

PMID34619994
PMCPMC8504275
OpenAlexW3204870457

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.