ArticleStroke2022
Brain Network Dysfunction in Poststroke Delirium and Spatial Neglect: An fMRI Study.
Article in Stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03349411 (Right Brain Stroke and the Neural Substrate of Delirium), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Right Brain Stroke and the Neural Substrate of Delirium
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Comparative efficacy of non-invasive brain stimulation for post-stroke cognitive impairment: a network meta-analysis.Aging clinical and experimental research · 2024Pooled it
- Advancing stroke diagnosis and management through nuclear medicine: a systematic review of clinical trials.Frontiers in medicine · 2024Pooled it
- Association between ePWV and delirium risk in icu sepsis patients: a retrospective analysis based on the MIMIC database and development of a predictive model.Clinics (Sao Paulo, Brazil) · 2026Article
- Cognitive Recovery After Poststroke Delirium (RECOVER): Protocol for a Longitudinal Multimodal Study on Cognitive Assessment in Patients With Stroke.JMIR research protocols · 2026Article
- Progress of nursing management for delirium in critically ill geriatric patients: a narrative review.Frontiers in human neuroscience · 2026Review
- Innovation in delirium care: A standardized intervention to reverse inattention using touch and movement.Journal of the American Geriatrics Society · 2025Article
- Current perspectives on the early identification and management of delirium after acute stroke reperfusion therapy.Frontiers in neurology · 2025Review
- Delirium in the ICU: how much do we know? A narrative review.Annals of medicine · 2024Review
- The Pathophysiology and Biomarkers of Delirium.Seminars in neurology · 2024Review
- Investigating delirium in stroke with an EEG lens: Focal lesions with global impact?Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Pupillometer-Based Neurological Pupil Index Differential: A Potential Predictor of Post-Stroke Delirium.Journal of stroke · 2024Article
- Serum NPTX2 as a Potential Predictive Biomarker for Postoperative Delirium in Patients with Acute Type A Aortic Dissection.Neuropsychiatric disease and treatment · 2024Article
- Neurophysiological patterns reflecting vulnerability to delirium subtypes: a resting-state EEG and event-related potential study.Brain communications · 2024Article
- Association of delirium and spatial neglect in patients with right-hemisphere stroke.PM & R : the journal of injury, function, and rehabilitation · 2023Article
- Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Review
- EEG microstate quantifiers and state space descriptors during anaesthesia in patients with postoperative delirium: a descriptive analysis.Brain communications · 2023Article
- Regional homogeneity alterations in multifrequency bands in patients with basal ganglia stroke: A resting-state functional magnetic resonance imaging study.Frontiers in aging neuroscience · 2022Article
- Recent advances in treatment of spatial neglect: networks and neuropsychology.Expert review of neurotherapeuticsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
background and purposeDelirium, an acute reduction in cognitive functioning, hinders stroke recovery and contributes to cognitive decline. Right-hemisphere stroke is linked with higher delirium incidence, likely, due to the prevalence of spatial neglect (SN), a right-brain disorder of spatial processing. This study tested if symptoms of delirium and SN after right-hemisphere stroke are associated with abnormal function of the right-dominant neural networks specialized for maintaining attention, orientation, and arousal.
methodsTwenty-nine participants with right-hemisphere ischemic stroke undergoing acute rehabilitation completed delirium and SN assessments and functional neuroimaging scans. Whole-brain functional connectivity of 4 right-hemisphere seed regions in the cortical-subcortical arousal and attention networks was assessed for its relationship to validated SN and delirium severity measures.
resultsOf 29 patients, 6 (21%) met the diagnostic criteria for delirium and 16 (55%) for SN. Decreased connectivity of the right basal forebrain to brain stem and basal ganglia predicted more severe SN. Increased connectivity of the arousal and attention network regions with the parietal, frontal, and temporal structures in the unaffected hemisphere was also found in more severe delirium and SN.
conclusionsDelirium and SN are associated with decreased arousal network activity and an imbalance of cortico-subcortical hemispheric connectivity. Better understanding of neural correlates of poststroke delirium and SN will lead to improved neuroscience-based treatment development for these disorders. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03349411.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.