Evidence map›Paper›PMID 34619980›Full record

ArticleAntioxidants & redox signaling2024

N-Acetylcysteine Inhibits Aortic Stenosis Progression in a Murine Model by Blocking Shear-Induced Activation of Platelet Latent Transforming Growth Factor Beta 1.

Sandeep Subrahmanian, Rohan Varshney, Kumar Subramani, Brennah Murphy, Sean Woolington, Jasimuddin Ahamed

Open access · greenAbstract read
In one paragraph

Article in Antioxidants & redox signaling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sandeep SubrahmanianCardiovascular Biology Research Program, Oklahoma Medical Research Foundation (OMRF), Oklahoma City, Oklahoma, USA.
Rohan VarshneyCardiovascular Biology Research Program, Oklahoma Medical Research Foundation (OMRF), Oklahoma City, Oklahoma, USA.
Kumar SubramaniCardiovascular Biology Research Program, Oklahoma Medical Research Foundation (OMRF), Oklahoma City, Oklahoma, USA.
Brennah MurphyCardiovascular Biology Research Program, Oklahoma Medical Research Foundation (OMRF), Oklahoma City, Oklahoma, USA.
Sean WoolingtonCardiovascular Biology Research Program, Oklahoma Medical Research Foundation (OMRF), Oklahoma City, Oklahoma, USA.
Jasimuddin AhamedCardiovascular Biology Research Program, Oklahoma Medical Research Foundation (OMRF), Oklahoma City, Oklahoma, USA.ORCID 0000-0001-6455-0296
Oklahoma Medical Research Foundation · US

Funding

Pilot ProjectP30GM114731 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI MCEVER, RODGER PAUL · 2016 to 2020
$6.5M
The Role of TGF-beta Activation and Signaling in Aortic Stenosis ProgressionR01HL148123 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI Jasimuddin Ahamed · 2020 to 2026
$2.9M
Cardiovascular Risk of Antiretroviral Therapy Drugs in HIVR01HL167656 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI Jasimuddin Ahamed · 2023 to 2026
$2.7M
The Mechanism of Shear-Induced Release and Activation of TGF-beta1R01HL123605 · NHLBI · ROCKEFELLER UNIVERSITY · PI AHAMED, JASIMUDDIN · 2015 to 2018
$1.7M
NHLBI NIH HHS R01 HL123605NHLBI NIH HHS R01 HL148123NHLBI NIH HHS R01 HL167656NIGMS NIH HHS P30 GM114731
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AcetylcysteineAortic Valve StenosisBlood PlateletsDisease Models, AnimalTransforming Growth Factor beta1AnimalsDisease ProgressionMiceMice, KnockoutReceptors, LDLStress, MechanicalAcetylcysteineReceptors, LDLTransforming Growth Factor beta1aortic stenosisN-acetylcysteineplatelet TGF-beta1reactive oxygen speciesshear

Identifiers

PMID34619980
PMCPMC11693965
OpenAlexW3204739660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.