ArticleNeuroImage. Clinical2021
Mood disorders disrupt the functional dynamics, not spatial organization of brain resting state networks.
Article in NeuroImage. Clinical, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Flexible brain state engagement predicts cognitive control transdiagnostically.bioRxiv : the preprint server for biology · 2026Article
- Dynamic coactivation patterns during repetitive negative thinking: A cross-sectional fMRI study.Psychological medicine · 2026Article
- Unraveling spatiotemporal dynamics in transdiagnosis subtypes of major depressive disorder and bipolar disorder: insights from co-activation patterns and treatment response.Molecular psychiatry · 2026Article
- Variation in moment-to-moment brain state engagement follows a consistent trajectory during development.Neuron · 2025Article
- Review of Dynamic Resting-State Methods in Neuroimaging: Applications to Depression and Rumination.Human brain mapping · 2025Review
- Dynamic neural network modulation associated with rumination in major depressive disorder: a prospective observational comparative analysis of cognitive behavioral therapy and pharmacotherapy.Translational psychiatry · 2025Observational
- Hippocampal temporal dynamics and spatial heterogeneity unveil vulnerability markers in the offspring of bipolar patients.Bipolar disorders · 2025Article
- Neural Variability and Cognitive Control in Individuals With Opioid Use Disorder.JAMA network open · 2025Article
- Underlying biological mechanisms of emotion dysregulation in bipolar disorder.Frontiers in psychiatry · 2025Review
- Coactivation pattern analysis reveals altered whole-brain functional transient dynamics in autism spectrum disorder.European child & adolescent psychiatry · 2024Article
- Human brain state dynamics are highly reproducible and associated with neural and behavioral features.PLoS biology · 2024Article
- Impact of a mindfulness-based intervention on neurobehavioral functioning and its association with large-scale brain networks in preterm young adolescents.Psychiatry and clinical neurosciences · 2024Article
- Human brain state dynamics reflect individual neuro-phenotypes.bioRxiv : the preprint server for biology · 2024Article
- Transient brain activity dynamics discriminate levels of consciousness during anesthesia.Communications biology · 2024Article
- A three-dimensional model of neural activity and phenomenal-behavioral patterns.Molecular psychiatry · 2024Review
- Abnormalities in Electroencephalographic Microstates in Patients with Late-Life Depression.Neuropsychiatric disease and treatment · 2024Article
- Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders.Neuronal signaling · 2023Review
- Altered Brain Dynamics Across Bipolar Disorder and Schizophrenia During Rest and Task Switching Revealed by Overlapping Brain States.Biological psychiatry · 2023Article
- Estimating dynamic individual coactivation patterns based on densely sampled resting-state fMRI data and utilizing it for better subject identification.Brain structure & function · 2023Article
- Large-scale brain network dynamics in very preterm children and relationship with socio-emotional outcomes: an exploratory study.Pediatric research · 2023Article
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5 authors.
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Abstract
Spontaneous fluctuations in the blood oxygenation level dependent signal measured through resting-state functional magnetic resonance imaging have been corroborated to aggregate into multiple functional networks. Abnormal resting brain activity is observed in mood disorder patients, however with inconsistent results. How do such alterations relate to clinical symptoms; e.g., level of depression and rumination tendencies? Here we recovered spatially and temporally overlapping functional networks from 31 mood disorder patients and healthy controls during rest, by applying novel methods that identify transient changes in spontaneous brain activity. Our unique approach disentangles the dynamic engagement of resting-state networks unconstrained by the slow hemodynamic response. This time-varying characterization provides moment-to-moment information about functional networks in terms of their durations and dynamic coupling, and offers novel evidence for selective contributionsto particular clinical symptoms. Patients showed increased duration of default-mode network (DMN), increased duration and occurrence of posterior DMN as well as insula- and amygdala-centered networks, but decreased occurrence of visual and anterior salience networks. Coupling between limbic (insula and amygdala) networks was also reduced. Depression level modulated DMN duration, whereas intrusive thoughts correlated with occurrence of insula and posterior DMN. Anatomical network organization was similar to controls. In sum, altered brain dynamics in mood disorder patients appear to mediate distinct clinical dimensions including increased self-processing, and decreased attention to external world.
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