Evidence map›Paper›PMID 34619569›Full record

ArticleDiagnostic microbiology and infectious disease2021

Kinetics of anti-SARS-CoV-2 IgG antibody levels and potential influential factors in subjects with COVID-19: A 11-month follow-up study.

Huanyuan Luo, Dorothée Camilleri, Ibon Garitaonandia, Dilshat Djumanov, Tao Chen, Ulrike Lorch, Jörg Täubel, Duolao Wang

Abstract read
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. SARS-CoV-2 antibodies persist up to 12 months after natural infection in healthy employees working in non-medical contact-intensive professions.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
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  8. Persistent humoral and CD4Frontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huanyuan LuoDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Dorothée CamilleriDepartment of Data Science, Richmond Pharmacology Ltd, London, UK.
Ibon GaritaonandiaRichmond Research Institute, St George's University of London, London, UK.
Dilshat DjumanovDepartment of Data Science, Richmond Pharmacology Ltd, London, UK.
Tao ChenDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
Ulrike LorchDepartment of Data Science, Richmond Pharmacology Ltd, London, UK.
Jörg TäubelDepartment of Data Science, Richmond Pharmacology Ltd, London, UK; Richmond Research Institute, St George's University of London, London, UK. Electronic address: j.taubel@richmondpharmacology.com.
Duolao WangDepartment of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK. Electronic address: duolao.wang@lstmed.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aim to study kinetics of anti-SARS-CoV-2 IgG antibody levels in subjects with COVID-19 for up to 11 months and the potential influential factors. The study was a prospective longitudinal study. The analyses were based on 77 serum/plasma samples with a mean of 4 samples per participant (range 1 - 18) in 20 participants with at least one positive Polymerase Chain Reaction testing result from 19 March 2020 up to 10 February 2021. Among the subjects (median age 34.5 years, 65% male), IgG level declined with the follow-up time (per month; geometric mean ratio [GMR] 0.73; 95% CI, 0.72 - 0.74). In a small sample of subjects from the general population with COVID-19, IgG levels declined non-linearly from month 2 to 11 with individual heterogeneity in quantity and changing speed and may be associated with gender, race and the loss of smell and taste.

Indexed as

AdultAgedAntibodies, ViralCOVID-19FemaleFollow-Up StudiesHumansImmunoglobulin GKineticsLongitudinal StudiesMaleMiddle AgedProspective StudiesSARS-CoV-2Time FactorsYoung AdultAntibodies, ViralImmunoglobulin GantibodycoronavirusCOVID-19IgGkineticsSARS-CoV-2

Identifiers

PMID34619569
PMCPMC8428032

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.