Evidence map›Paper›PMID 34619262›Full record

ArticleInternational journal of cardiology2021

Pre-admission acetylsalicylic acid therapy and impact on in-hospital outcome in COVID-19 patients: The ASA-CARE study.

Antonio Sisinni, Luca Rossi, Antonio Battista, Enrico Poletti, Federica Battista, Rosa Alessia Battista, Alessandro Malagoli, Andrea Biagi, Alessia Zanni, Concetta Sticozzi and 8 more

Abstract read
In one paragraph

Article in International journal of cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Observational
  10. Review
  11. Further evidence for the use of aspirin in COVID-19.International journal of cardiology · 2022
    Article
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Antonio SisinniCardiology Unit, IRCCS Policlinico San Donato, Milan, Italy; Università degli studi di Milano, Milan, Italy.
Luca RossiDivision of Cardiology, Cardiovascular and Emergency Department, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Antonio BattistaEmergency Department, Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.
Enrico PolettiCardiology Unit, IRCCS Policlinico San Donato, Milan, Italy; Università degli studi di Milano, Milan, Italy.
Federica BattistaUniversità degli studi di Pavia, Pavia, Italy.
Rosa Alessia BattistaUniversità̀ Vita-Salute San Raffaele, Milano, Italy.
Alessandro MalagoliDivision of Cardiology, Cardiovascular and Emergency Department, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Andrea BiagiDivision of Cardiology, Cardiovascular and Emergency Department, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Alessia ZanniDivision of Cardiology, Cardiovascular and Emergency Department, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Concetta SticozziDivision of Cardiology, Cardiovascular and Emergency Department, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Greta ComastriDivision of Cardiology, Cardiovascular and Emergency Department, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Massimiliano M Marrocco-TrischittaClinical Research Unit, Cardiovascular Department, IRCCS Policlinico San Donato, Milan, Italy.
Alberto MonelloDivision of Cardiology, Cardiovascular and Emergency Department, Guglielmo da Saliceto Hospital, Piacenza, Italy.
Alberto MargonatoUniversità̀ Vita-Salute San Raffaele, Milano, Italy; Cardiovascular Department, San Raffaele Scientific Institute, Milan, Italy.
Francesco BanderaCardiology Unit, IRCCS Policlinico San Donato, Milan, Italy; Università degli studi di Milano, Milan, Italy.
Pasquale VergaraArrhythmias and Cardiac Electrophysiology, San Raffaele Scientific Institute, Milan, Italy.
Marco GuazziUniversità degli studi di Milano, Milan, Italy.
Cosmo GodinoUniversità̀ Vita-Salute San Raffaele, Milano, Italy; Cardiovascular Department, San Raffaele Scientific Institute, Milan, Italy. Electronic address: cosmogodino@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with coronavirus disease 2019 (COVID-19) exhibit high thrombotic risk. The evidence on a potential independent prognostic role of antiplatelet treatment in those patients is limited. The aim of the study was to evaluate the prognostic impact of pre-admission low-dose acetylsalicylic acid (ASA) in a wide series of hospitalized patients with COVID-19.

methodsThis cohort study included 984 COVID-19 patients stratified according to ASA intake before hospitalization: ASA

resultsMean age was 72 [62; 81] with 69% of male patients. ASA

conclusionsIn COVID-19 patients undergoing hospitalization, pre-admission treatment with ASA is associated with better in-hospital outcome, mainly driven by less respiratory support upgrade.

Indexed as

AspirinCOVID-19AgedCohort StudiesHospitalizationHospital MortalityHospitalsHumansMaleSARS-CoV-2AspirinAcetylsalicylic acidCOVID-19Platelet aggregation inhibitorsSARS-CoV-2Thrombosis

Identifiers

PMID34619262
PMCPMC8489263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.