Evidence map›Paper›PMID 34619105›Full record

ReviewThe lancet. Diabetes & endocrinology2021

COVID-19 and metabolic disease: mechanisms and clinical management.

Charlotte Steenblock, Peter E H Schwarz, Barbara Ludwig, Andreas Linkermann, Paul Zimmet, Konstantin Kulebyakin, Vsevolod A Tkachuk, Alexander G Markov, Hendrik Lehnert, Martin Hrabě de Angelis and 26 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The lancet. Diabetes & endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 7 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 7 syntheses or guidelines pooled it, 244 citations in OpenAlex.

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  7. New-Onset Diabetes Mellitus, Hypertension, Dyslipidaemia as Sequelae of COVID-19 Infection-Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors at 20 institutions in 19 countries.

Charlotte SteenblockDepartment of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Peter E H SchwarzDepartment of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Paul Langerhans Institute Dresden, Helmholtz Center Munich, University Hospital Carl Gustav Carus, Dresden, Germany; German Center for Diabetes Research, Neuherberg, Germany.
Barbara LudwigDepartment of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; DFG-Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany; Paul Langerhans Institute Dresden, Helmholtz Center Munich, University Hospital Carl Gustav Carus, Dresden, Germany; German Center for Diabetes Research, Neuherberg, Germany; Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland.
Andreas LinkermannDepartment of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Paul ZimmetDepartment of Diabetes, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Konstantin KulebyakinDepartment of Biochemistry and Molecular Medicine, Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia; Institute for Regenerative Medicine, Medical Research and Education Centre, Lomonosov Moscow State University, Moscow, Russia.
Vsevolod A TkachukDepartment of Biochemistry and Molecular Medicine, Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia; Institute for Regenerative Medicine, Medical Research and Education Centre, Lomonosov Moscow State University, Moscow, Russia.
Alexander G MarkovDepartment of General Physiology, St Petersburg State University, St Petersburg, Russia.
Hendrik LehnertParis Lodron University Salzburg, Salzburg, Austria.
Martin Hrabě de AngelisGerman Center for Diabetes Research, Neuherberg, Germany; Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany; School of Life Sciences, Technische Universität München, Freising, Germany.
Hannes RietzschDepartment of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Roman N RodionovDepartment of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Kamlesh KhuntiDiabetes Research Centre, University of Leicester, Leicester, UK.
David HopkinsDepartment of Diabetes, School of Life Course Science and Medicine, Kings College London, London, UK.
Andreas L BirkenfeldDepartment of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Department of Diabetes, School of Life Course Science and Medicine, Kings College London, London, UK; Department of Diabetology, Endocrinology and Nephrology, University Hospital Tübingen, Tübingen, Germany; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich, University of Tübingen, Tübingen, Germany; Deutsches Zentrum für Diabetesforschung, Neuherberg, Germany.
Bernhard BoehmDepartment of Endocrinology, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Richard I G HoltHuman Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
Jay S SkylerDiabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
J Hans DeVriesAmsterdam UMC, Internal Medicine, University of Amsterdam, Amsterdam, Netherlands; Profil Institute for Metabolic Research, Neuss, Germany.
Eric RenardDepartment of Endocrinology, Diabetes, Nutrition, Montpellier University Hospital, Montpellier, France; Institute of Functional Genomics, University of Montpellier, INSERM, CNRS, Montpellier, France.
Robert H EckelDivision of Endocrinology, Metabolism, and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
K George M M AlbertiImperial College London, London, UK.
Bruno GelonezeObesity and Comorbidities Research Center, Universidade de Campinas, Campinas, Brazil.
Juliana C ChanDepartment of Medicine and Therapeutics, Hong Kong Institute of Diabetes and Obesity, Hong Kong Special Administrative Region, China; Li Ka Shing Institute of Health Science, Chinese University of Hong Kong and Prince of Wales Hospital, Hong Kong Special Administrative Region, China.
Jean Claude MbanyaDepartment of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé, Yaounde, Cameroon.
Henry C OnyegbutulemEndocrine, Diabetes and Metabolic Unit, Department of Internal Medicine, Nile University of Nigeria-Asokoro Hospital, Abuja, Nigeria.
Ambady RamachandranIndia Diabetes Research Foundation, Dr A Ramachandran's Diabetes Hospitals, Chennai, India.
Abdul BasitBaqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, Pakistan.
Mohamed HassaneinDubai Hospital, Dubai Health Authority and Gulf Medical University, Dubai, United Arab Emirates.
Gavin BewickDepartment of Diabetes, School of Life Course Science and Medicine, Kings College London, London, UK.
Giatgen A SpinasDepartment of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland.
Felix BeuschleinDepartment of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland.
Rüdiger LandgrafGerman Diabetes Foundation, Düsseldorf, Germany.
Francesco RubinoDepartment of Diabetes, School of Life Course Science and Medicine, Kings College London, London, UK; Bariatric and Metabolic Surgery, King's College Hospital, London, UK.
Geltrude MingroneDepartment of Diabetes, School of Life Course Science and Medicine, Kings College London, London, UK; Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Università Cattolica del Sacro Cuore, Rome, Italy.
Stefan R BornsteinDepartment of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Paul Langerhans Institute Dresden, Helmholtz Center Munich, University Hospital Carl Gustav Carus, Dresden, Germany; German Center for Diabetes Research, Neuherberg, Germany; Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland; Department of Diabetes, School of Life Course Science and Medicine, Kings College London, London, UK. Electronic address: stefan.bornstein@uniklinikum-dresden.de.
King's College London · GBTechnische Universität Dresden · DELomonosov Moscow State University · RUUniversity Hospital of Zurich · CHAgostino Gemelli University Polyclinic · ITAmsterdam University Medical Centers · NLBaqai Medical University · PKCentre Hospitalier Universitaire de Montpellier · FRChinese University of Hong Kong · HKDeutsche Diabetes Stiftung · DEDr. A. Ramachandran's Diabetes Hospitals · INDubai Hospital · AEGerman Center for Diabetes Research · DEHeinrich Heine University Düsseldorf · DEImperial College London · GBMonash University · AUNile University of Nigeria · NGPaul Langerhans Institute Dresden · DESt Petersburg University · RUTan Tock Seng Hospital · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Up to 50% of the people who have died from COVID-19 had metabolic and vascular disorders. Notably, there are many direct links between COVID-19 and the metabolic and endocrine systems. Thus, not only are patients with metabolic dysfunction (eg, obesity, hypertension, non-alcoholic fatty liver disease, and diabetes) at an increased risk of developing severe COVID-19 but also infection with SARS-CoV-2 might lead to new-onset diabetes or aggravation of pre-existing metabolic disorders. In this Review, we provide an update on the mechanisms of how metabolic and endocrine disorders might predispose patients to develop severe COVID-19. Additionally, we update the practical recommendations and management of patients with COVID-19 and post-pandemic. Furthermore, we summarise new treatment options for patients with both COVID-19 and diabetes, and highlight current challenges in clinical management.

Indexed as

Disease ManagementAngiotensin-Converting Enzyme 2COVID-19Diabetes MellitusHumansHypertensionMetabolic DiseasesNon-alcoholic Fatty Liver DiseaseObesityACE2 protein, humanAngiotensin-Converting Enzyme 2

Identifiers

PMID34619105
PMCPMC8489878
OpenAlexW3202042764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.