Evidence map›Paper›PMID 34618885›Full record

ArticleThe Journal of infectious diseases2022

Severe Acute Respiratory Syndrome Coronavirus 2 RNAemia and Clinical Outcomes in Children With Coronavirus Disease 2019.

Cameron Mertz, Rebecca Glowinski, Shira H Cohen, Sara Mertz, Fang Ye, Mark W Hall, Mark E Peeples, Tiffany King, Huanyu Wang, Amy L Leber and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Cameron MertzCenter for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, Ohio, USA.
Rebecca GlowinskiCenter for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, Ohio, USA.
Shira H CohenCenter for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, Ohio, USA.
Sara MertzCenter for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, Ohio, USA.
Fang YeCenter for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, Ohio, USA.
Mark W HallDepartment of Pediatrics, Division of Critical Care Medicine, Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, Ohio, USA.
Mark E PeeplesCenter for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, Ohio, USA.
Tiffany KingCenter for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, Ohio, USA.
Huanyu WangDepartment of Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.
Amy L LeberDepartment of Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA.
Pablo J SanchezCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, Ohio, USA.
Octavio RamiloCenter for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, Ohio, USA.
Asuncion MejiasCenter for Vaccines and Immunity, The Abigail Wexner Research Institute at Nationwide Children's Hospital, and The Ohio State University College of Medicine, Columbus, Ohio, USA.ORCID 0000-0002-5983-8006
Nationwide Children's Hospital · US

Funding

High Precision System Analysis of Infant Immune ResponsesU01AI131386 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI RAMILO, OCTAVIO, SANCHEZ, PABLO J · 2017 to 2021
$6.3M
Nationwide Children's HospitalNIAID NIH HHS U01 AI131386NIH HHS AI131386
6 · The paper itself

Abstract

The burden of coronavirus disease 2019 (COVID-19) in children represents a fraction of cases worldwide, yet a subset of those infected are at risk for severe disease. We measured plasma severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in a cohort of 103 children hospitalized with COVID-19 with diverse clinical manifestations. SARS-CoV-2 RNAemia was detected in 27 (26%) of these children, lasted for a median of 6 (interquartile range, 2-9) days, and was associated with higher rates of oxygen administration, admission to the intensive care unit, and longer hospitalization.

Indexed as

AdolescentChildChild, PreschoolCOVID-19COVID-19 Nucleic Acid TestingFemaleHospitalizationHumansInfantIntensive Care UnitsMaleNasopharynxRNA, ViralSARS-CoV-2Severity of Illness IndexViremiaRNA, ViralchildrenCOVID-19disease severityinfantsoutcomesRNAemiaSARS-CoV-2viremia

Identifiers

PMID34618885
PMCPMC8763956
OpenAlexW3203598127

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.