Evidence map›Paper›PMID 34618597›Full record

ArticleThe British journal of radiology2022

T2-FLAIR mismatch sign: a roadmap of pearls and pitfalls.

Catarina Pinto, Carolina Noronha, Ricardo Taipa, Cristina Ramos

Abstract read
In one paragraph

Article in The British journal of radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Beyond the visual T2-FLAIR mismatch: quantitative imaging markers of IDH mutation in Gliomas-A retrospective diagnostic accuracy study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  11. T2-FLAIR Mismatch Sign Predicts DNA Methylation Subclass and CDKN2A/B Status in IDH-Mutant Astrocytomas.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Catarina PintoNeuroradiology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.ORCID 0000-0003-0801-1153
Carolina NoronhaNeurosurgery Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Ricardo TaipaNeuropathology Unit, Department of Neurosciences, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Cristina RamosNeuroradiology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T2-FLAIR mismatch sign has been advocated to be 100% specific for IDH-mutant 1p/19q non-codeleted gliomas (diffuse astrocytomas). However, false positives have been reported in recent works. Loose application of the criteria may lead to erroneous classification, especially by non-trained neuroradiologists. In this pictorial essay, we aim to bring attention to the need for strict criteria for the application of T2-FLAIR mismatch sign and to discuss the potential pitfalls in the application of these criteria. For that, a series of adult brain tumour cases are presented to demonstrate how to apply this radiological sign in the clinical practice.

Indexed as

Magnetic Resonance ImagingBrainBrain NeoplasmsChromosomes, Human, Pair 1Chromosomes, Human, Pair 19GliomaHumansImage Interpretation, Computer-AssistedIsocitrate DehydrogenaseMutationNeuroimagingIsocitrate Dehydrogenase

Identifiers

PMID34618597
PMCPMC8722227

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.