ArticleScience (New York, N.Y.)2021
Population-specific neuromodulation prolongs therapeutic benefits of deep brain stimulation.
Article in Science (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of deep brain stimulation for substance use disorders.Translational psychiatry · 2024Pooled it
- Printing-Assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Burst deep brain stimulation for Parkinson's disease: A systematic review of efficacy and safety.Journal of Parkinson's disease · 2026Review
- Harnessing synaptic plasticity for sustained motor improvement in Parkinson's disease.Neural regeneration research · 2026Article
- Compensatory coupling between leak and HCN conductances defines a low dimensional solution manifold in GPe neuron subtypes.Scientific reports · 2026Article
- Distinct modes of dopamine modulation on striatopallidal synaptic transmission.Nature communications · 2026Article
- Human and mouse cerebellar inhibitory circuits in dystonic crisis and their modulation with therapeutic stimulation.bioRxiv : the preprint server for biology · 2026Article
- Deep brain stimulation reduces subthalamic nucleus pathological dynamics and rescues gait deficits associated with dopamine loss.bioRxiv : the preprint server for biology · 2026Article
- Differential effects of focused ultrasound neuromodulation in Parkinson's disease mice versus healthy mice.Journal of neural engineering · 2026Article
- Treadmill exercise rescues motor deficits in parkinsonian mice by modulating striatal D2-MSN activity: evidence from calcium imaging and chemogenetics.Frontiers in systems neuroscience · 2026Article
- Exercise evokes retained motor performance without neuroprotection in a mouse model of Parkinson's disease.Frontiers in physiology · 2026Article
- Adaptive neuromodulation dialogues: navigating current challenges and emerging innovations in neuromodulation system development.Journal of neural engineering · 2025Review
- Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans.Nature neuroscience · 2025Review
- Differential synaptic depression mediates the therapeutic effect of deep brain stimulation.Nature neuroscience · 2025Article
- Calcium-based synaptic and structural plasticity link pathological activity to synaptic reorganization in Parkinson's disease.Science advances · 2025Article
- Surprises From the Basal Ganglia: Stop and Go Have New Meaning.Movement disorders : official journal of the Movement Disorder Society · 2025Review
- Restoration of locomotor function following stimulation of the A13 region in Parkinson's mouse models.eLife · 2025Article
- Striatal pathways oppositely shift cortical activity along the decision axis.bioRxiv : the preprint server for biology · 2025Article
- Modulating inhibitory synaptic plasticity to restore basal ganglia dynamics in Parkinson's disease.Brain : a journal of neurology · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Symptoms of neurological diseases emerge through the dysfunction of neural circuits whose diffuse and intertwined architectures pose serious challenges for delivering therapies. Deep brain stimulation (DBS) improves Parkinson’s disease symptoms acutely but does not differentiate between neuronal circuits, and its effects decay rapidly if stimulation is discontinued. Recent findings suggest that optogenetic manipulation of distinct neuronal subpopulations in the external globus pallidus (GPe) provides long-lasting therapeutic effects in dopamine-depleted (DD) mice. We used synaptic differences to excite parvalbumin-expressing GPe neurons and inhibit lim-homeobox-6–expressing GPe neurons simultaneously using brief bursts of electrical stimulation. In DD mice, circuit-inspired DBS provided long-lasting therapeutic benefits that far exceeded those induced by conventional DBS, extending several hours after stimulation. These results establish the feasibility of transforming knowledge of circuit architecture into translatable therapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.