ArticleScience immunology2021
SARS-CoV-2 infection generates tissue-localized immunological memory in humans.
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Article in Science immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers.
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151citing papers in PubMed
12.4field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
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Who cites it
151 citing papers in PubMed, 228 citations in OpenAlex.
- Humoral and cellular immune responses to CoronaVac up to one year after vaccination.Frontiers in immunology · 2022Trial
- Review
- Article
- The Role of CD4 T Cell Repertoire and Immune Memory Mechanisms in Vaccination and Infection Immunity.Immunological reviews · 2026Review
- Beyond the blood: Tissue-resident immunity shapes SARS-CoV-2 vaccine antibody responses.bioRxiv : the preprint server for biology · 2026Article
- Combating respiratory diseases with mucosal vaccines.Journal of virology · 2026Review
- Compartment-specific phase compensation between pulmonary T-Cell immunity and waning systemic responses in BA.5 breakthrough infection.Respiratory research · 2026Article
- Local B cell immunity and durable memory after live-attenuated influenza intranasal vaccination of humans.Science translational medicine · 2026Article
- Antiretroviral therapy interferes with pseudovirus neutralization assays while Gag-specific T-cells influence mRNA vaccine outcomes in HIV patients.Scientific reports · 2026Article
- Immunological memory to vaccines.Immunity · 2026Review
- The B cell receptor-mTOR signaling axis restricts the accumulation of lung tissue-resident memory B cells after influenza infection.Science immunology · 2026Article
- Distinct commensal bacteria in human nasopharyngeal lymphoid tissue associated with localized immunological memory.iScience · 2026Article
- Review
- Lung tissue-resident memory T cells optimize protection by IL-10 regulation of innate immunity.The Journal of experimental medicine · 2026Article
- Capturing the full spectrum of T cell responses with spectral flow cytometry.Oxford open immunology · 2026Review
- Prolonged persistence of tissue-resident memory cells in the upper airway following SARS-CoV-2 infection and vaccination.Clinical & translational immunology · 2026Article
- Adenoviral vector oropharyngeal spray immunization elicits mucosal immunity and protects against heterologous SARS-CoV-2 infection.NPJ vaccines · 2025Article
- Article
- Detection and Validation of Influenza Virus Hemagglutinin Specific, Cross-Reactive, and Heteroclitic B Cells Induced by a Combination Vaccine Adjuvant.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2025Article
- Sustained Lung Inflammation Post-SARS-CoV-2 Infection in Mice Is Associated with Increased Pulmonary T Cells.European journal of immunology · 2025Article
91 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 3 institutions in 1 country.
Maya M L PoonDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-7927-5853
Ksenia RybkinaDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Yu KatoCenter of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0003-4743-1775
Masaru KubotaDepartment of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-4095-738X
Rei MatsumotoDepartment of Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA.
Nathaniel I BloomCenter of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-6338-9098
Zeli ZhangCenter of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Kathryn M HastieCenter of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-3406-1210
Alba GrifoniCenter of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-2209-5966
Daniela WeiskopfCenter of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0003-2968-7371
Steven B WellsDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Basak B UralDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0003-0671-2933
Nora LamDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-8933-3121
Peter A SzaboDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0003-1603-761X
Pranay DograDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0003-2031-9855
Yoon S LeeDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-9988-8905
Joshua I GrayDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0003-2796-5470
Marissa C BradleyDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA.
Maigan A BruskoDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0002-4331-2202
Todd M BruskoDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611, USA.ORCID 0000-0003-2878-9296
Erica O SaphireCenter of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-1206-7451
Thomas J ConnorsDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-0199-7733
Alessandro SetteCenter of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0001-7013-2250
Shane CrottyCenter of Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-6484-6262
Donna L FarberDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0001-8236-9183
Columbia University Irving Medical Center · USLa Jolla Institute for Immunology · USUniversity of Florida · US
Funding
T follicular helper (Tfh) CD4+ T cell, germinal center, and antibody response dysfunction in human recurrent tonsillitisU19AI142742 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Alessandro Sette · 2019 to 2026
$32.8MTranscriptomics and Repertoire ProfilingP01AI106697 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2013 to 2026
$31.3MViral Assays CoreU19AI128949 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber, Peter Alan Sims · 2017 to 2026
$26.4MDevelopment of lung T cell responses in infant respiratory immunityU01AI100119 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FARBER, DONNA L. · 2017 to 2021
$3.9MDevelopment of lung T cell responses in infant respiratory immunityR01AI100119 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FARBER, DONNA L. · 2012 to 2016
$2.6MImmunobiology and alveolar physiology of the aging lungU01HL145547 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BHATTACHARYA, JAHAR, FARBER, DONNA L. · 2019 to 2022
$2.6MDevelopment of Localized T Cell Immunity in Pediatric Respiratory Tract InfectionK23AI141686 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CONNORS, THOMAS · 2019 to 2023
$973kBD Biosciences InfluxS10OD020056 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2015 to 2015
$600kBecton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413kNCRR NIH HHS S10 RR027050NHLBI NIH HHS U01 HL145547NIAID NIH HHS K23 AI141686NIAID NIH HHS P01 AI106697NIAID NIH HHS R01 AI100119NIAID NIH HHS U01 AI100119NIAID NIH HHS U19 AI128949NIAID NIH HHS U19 AI142742NIH HHS S10 OD020056
Abstract
Adaptive immune responses to SARS-CoV-2 infection have been extensively characterized in blood; however, most functions of protective immunity must be accomplished in tissues. Here, we report from examination of SARS-CoV-2 seropositive organ donors (ages 10 to 74) that CD4
Indexed as
Immunity, CellularImmunologic MemoryAntibodies, ViralCOVID-19FemaleHumansLymphocytesMaleOrgan SpecificitySARS-CoV-2Antibodies, Viral
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