ArticleAnalytical chemistry2021
Nontargeted Analysis Study Reporting Tool: A Framework to Improve Research Transparency and Reproducibility.
Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed.
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- Identification of Emerging Organic Pollutants in Aquatic Environments Under the Omics-Based Framework: A Review.Molecules (Basel, Switzerland) · 2026Review
- Comprehensive pollutant screening in honey using integrated targeted and non-targeted LC-Q-Orbitrap HRMS.Analytical and bioanalytical chemistry · 2026Article
- Untargeted LC-HRMS Metabolomics for the Detection of Alternaria-Infected Apples Under Retail and Storage Conditions.Toxins · 2026Article
- Quantifying PFAS-Omics Burden Scores for Nontargeted Analysis Using Multidimensional Item Response Theory: An Exploratory Analysis of Novel and Legacy PFAS in Cord Blood.Environmental science & technology · 2026Article
- The PFAS roadmap-Navigating a path together to improved management.Sustainability science and technology · 2026Article
- Exposomics as a discovery engine for emerging contaminants and hidden biological risks.Emerging contaminants · 2026Article
- From the Road to the Field: Decoding Chemical Transformation in Aging Tire and Artificial Turf Crumb Rubber.Environmental science & technology · 2026Article
- The data substrate of exposome intelligence: an interoperability profile for untargeted metabolomics.Frontiers in artificial intelligence · 2026Article
- Securing the Future of NMR Metabolomics Reproducibility: A Call for Standardized Reporting.Analytical chemistry · 2025Review
- Updated Guidance for Communicating PFAS Identification Confidence with Ion Mobility Spectrometry.Environmental science & technology · 2025Article
- Enhancing the Detectable Chemical Space in an Effluent-Dominated Stream: Non-Target Analysis Reveals Potential RapidEnvironmental science & technology letters · 2025Article
- Exploring Domestic Discharge Patterns in Wastewater through LC-HRMS Screening and Temporal Clustering.Environmental science & technology · 2025Article
- Prioritizing Chemical Candidates from Non-targeted Analysis Using Metadata, Spectral Similarity, and Hazard Scoring within INTERPRET NTA.Analytical chemistry · 2025Article
- Examining structure-based surrogate selection for quantitative non-targeted analysis.Analytical and bioanalytical chemistry · 2025Article
- Suspect screening of bisphenol A (BPA) structural analogues and functional alternatives in human milk from Canada and South Africa.Journal of exposure science & environmental epidemiology · 2025Article
- Article
- Applying Nontargeted Analysis to Explore the Chemical Composition of Dust Collected in Infants' Homes.Environmental science & technology · 2025Article
- Practical Considerations of FDA's CLAP List to Support Testing of Extractables for Pharmaceuticals and Medical Devices.ACS omega · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Non-targeted analysis (NTA) workflows using mass spectrometry are gaining popularity in many disciplines, but universally accepted reporting standards are nonexistent. Current guidance addresses limited elements of NTA reporting-most notably, identification confidence-and is insufficient to ensure scientific transparency and reproducibility given the complexity of these methods. This lack of reporting standards hinders researchers' development of thorough study protocols and reviewers' ability to efficiently assess grant and manuscript submissions. To overcome these challenges, we developed the NTA Study Reporting Tool (SRT), an easy-to-use, interdisciplinary framework for comprehensive NTA methods and results reporting. Eleven NTA practitioners reviewed eight published articles covering environmental, food, and health-based exposomic applications with the SRT. Overall, our analysis demonstrated that the SRT provides a valid structure to guide study design and manuscript writing, as well as to evaluate NTA reporting quality. Scores self-assigned by authors fell within the range of peer-reviewer scores, indicating that SRT use for self-evaluation will strengthen reporting practices. The results also highlighted NTA reporting areas that need immediate improvement, such as analytical sequence and quality assurance/quality control information. Although scores intentionally do not correspond to data/results quality, widespread implementation of the SRT could improve study design and standardize reporting practices, ultimately leading to broader use and acceptance of NTA data.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.