Evidence map›Paper›PMID 34618223›Full record

ArticleJournal of neurology2022

Brain network topology and future development of freezing of gait in Parkinson's disease: a longitudinal study.

Nannan Li, Du Lei, Jiaxin Peng, Xueling Suo, Junying Li, Liren Duan, Chaolan Chen, Qiyong Gong, Rong Peng

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Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Topography of Regional Cerebral GABAThe European journal of neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nannan LiDepartment of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, Sichuan, China.
Du LeiDepartment of Radiology, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Jiaxin PengDepartment of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, Sichuan, China.
Xueling SuoDepartment of Radiology, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Junying LiDepartment of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, Sichuan, China.
Liren DuanDepartment of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, Sichuan, China.
Chaolan ChenDepartment of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, Sichuan, China.
Qiyong GongDepartment of Radiology, Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Rong PengDepartment of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, Sichuan, China. qrongpeng@126.com.ORCID http://orcid.org/0000-0002-0373-6035

Funding

Department of Science and Technology of Sichuan Province 2018HH0077Fundamental Research Funds for the Central Universities 2018SCU12029National Natural Science Foundation of China 81801272West China Hospital, Sichuan University 2018HXBH085
6 · The paper itself

Abstract

backgroundFreezing of gait (FOG) is a common disabling gait disturbance in Parkinson's disease (PD). The objectives of this study were to explore alterations in the topological organization of whole-brain functional networks in patients with PD who will develop FOG.

methodsWe recruited 20 patients with PD who developed FOG (PD-FOGt) during a 5-year follow-up period, 20 patients with PD who did not developed FOG (PD-FOGn) within the follow-up period, and 20 healthy control subjects. Using graph theory approaches, we performed a comparative analysis of the topological organization of whole-brain functional networks among the groups, and further explored their potential relationships with latency to develop FOG.

resultsAt baseline, the global topological properties of functional brain networks in PD-FOGt and PD-FOGn showed no abnormalities. Additionally, regarding regional topological properties, compared with PD-FOGn patients, PD-FOGt patients exhibited decreased nodal centrality in the left middle frontal gyrus (MFG). Although there were no significant differences compared with PD-FOGn patients, the PD-FOGt group exhibited the lowest nodal centrality values in the frontal cortex (left gyrus rectus), and visual cortex (bilateral inferior occipital gyrus and left fusiform gyrus), and the highest nodal centrality values in the cerebellum (vermis_6) among the three groups. However, no relationship was found between the nodal centrality in above brain regions and latency to develop FOG.

conclusionThis study demonstrates the disrupted regional topological organization might contribute to the future development of FOG in PD patients, especially associated with damage to the left MFG.

Indexed as

Gait Disorders, NeurologicParkinson DiseaseBrainGaitHumansLongitudinal StudiesMagnetic Resonance ImagingBrain networksFreezing of gaitGraph theoryMagnetic resonance imagingParkinson’s disease

Identifiers

PMID34618223

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.