ArticlePlant physiology2021
HECATE2 acts with GLABROUS3 and Tu to boost cytokinin biosynthesis and regulate cucumber fruit wart formation.
Article in Plant physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Molecular Targets and Trait Innovation in CRISPR-Edited Vegetable Crops: An Up-to-Date Review (2020-2026).Plants (Basel, Switzerland) · 2026Review
- A Novel AP2/ERF Transcription Factor Controls Trichome Initiation and Fruit Development in Cucumber.Plant biotechnology journal · 2026Article
- ENHANCER OF SHOOT REGENERATION 1 (ESR1) functions in trichome initiation in cucumber (Cucumis sativus L.).The Plant journal : for cell and molecular biology · 2026Article
- Novel 2-aminothiazole derivatives incorporating 9-alkyl purine moiety: design, synthesis, crystal structure, and bioactivity evaluation.Molecular diversity · 2026Article
- The role, regulation and application of plant fruit trichomes.Molecular horticulture · 2025Review
- Multifunctional Role of Cytokinin in Horticultural Crops.International journal of molecular sciences · 2025Review
- Regulatory mechanisms of trichome and root hair development in Arabidopsis.Plant molecular biology · 2024Review
- Mutations in a Leucine-Rich Repeat Receptor-Like Kinase gene result in male sterility and reduction in the number and size of fruit warts in cucumber (Cucumis sativus L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- NIN-LIKE PROTEIN3.2 inhibits repressor Aux/IAA14 expression and enhances root biomass in maize seedlings under low nitrogen.The Plant cell · 2024Article
- CmERF1 acts as a positive regulator of fruits and leaves growth in melon (Cucumis melo L.).Plant molecular biology · 2024Article
- Heterotrimeric Gα-subunit regulates flower and fruit development in CLAVATA signaling pathway in cucumber.Horticulture research · 2024Article
- CRISPR-Cas9 based molecular breeding in crop plants: a review.Molecular biology reports · 2024Review
- CucumberAI: Cucumber Fruit Morphology Identification System Based on Artificial Intelligence.Plant phenomics (Washington, D.C.) · 2024Article
- Advances in understanding epigenetic regulation of plant trichome development: a comprehensive review.Horticulture research · 2023Article
- CRISPR/Cas9 gene editing technology: a precise and efficient tool for crop quality improvement.Planta · 2023Review
- Regulation of capsule spine formation in castor.Plant physiology · 2023Article
- Natural variation in CRABS CLAW contributes to fruit length divergence in cucumber.The Plant cell · 2023Article
- Applications of CRISPR/Cas genome editing in economically important fruit crops: recent advances and future directions.Molecular horticulture · 2023Review
- Plant breeding advancements with "CRISPR-Cas" genome editing technologies will assist future food security.Frontiers in plant science · 2023Review
- Morphological and Genetic Diversity of Cucumber (Plants (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Warty fruit in cucumber (Cucumis sativus L.) is an important quality trait that greatly affects fruit appearance and market value. The cucumber wart consists of fruit trichomes (spines) and underlying tubercules, in which the existence of spines is prerequisite for tubercule formation. Although several regulators have been reported to mediate spine or tubercule formation, the direct link between spine and tubercule development remains unknown. Here, we found that the basic Helix-Loop-Helix (bHLH) gene HECATE2 (CsHEC2) was highly expressed in cucumber fruit peels including spines and tubercules. Knockout of CsHEC2 by the CRISPR/Cas9 system resulted in reduced wart density and decreased cytokinin (CTK) accumulation in the fruit peel, whereas overexpression of CsHEC2 led to elevated wart density and CTK level. CsHEC2 is directly bound to the promoter of the CTK hydroxylase-like1 gene (CsCHL1) that catalyzes CTK biosynthesis, and activated CsCHL1 expression. Moreover, CsHEC2 physically interacted with GLABROUS3 (CsGL3, a key spine regulator) and Tuberculate fruit (CsTu, a core tubercule formation factor), and such interactions further enhanced CsHEC2-mediated CsCHL1 expression. These data suggested that CsHEC2 promotes wart formation by acting as an important cofactor for CsGL3 and CsTu to directly stimulate CTK biosynthesis in cucumber. Thus, CsHEC2 can serve as a valuable target for molecular breeding of cucumber varieties with different wart density requirements.
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