ArticlePlant physiology2021
IRONMAN tunes responses to iron deficiency in concert with environmental pH.
Article in Plant physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- CARK3-mediated phosphorylation of bHLH106 inhibits iron uptake by repressing the expression of IRT1 in Arabidopsis.Plant communications · 2026Article
- The SVP-FRO6 Module Integrates the Control of Leaf Senescence and Flowering in Arabidopsis.Plant, cell & environment · 2026Article
- The Arabidopsis NPF7.2 mediates coumarin uptake for root iron acquisition.The New phytologist · 2026Article
- Cooperation between a root fungal endophyte and host-derived coumarin scopoletin mediates Arabidopsis iron nutrition.The New phytologist · 2025Article
- The biosynthetic pathway of coumarin and its genetic regulation in response to biotic and abiotic stresses.Frontiers in plant science · 2025Review
- Transcriptome analysis of iron over-accumulating Arabidopsis genotypes uncover putative novel regulators of systemic and retrograde signaling.The plant genome · 2024Article
- A major role of coumarin-dependent ferric iron reduction in strategy I-type iron acquisition in Arabidopsis.The Plant cell · 2024Article
- Iron Availability Influences Protein Carbonylation inInternational journal of molecular sciences · 2023Article
- Iron Nutrition in Plants: Towards a New Paradigm?Plants (Basel, Switzerland) · 2023Review
- Alkalinity modulates a unique suite of genes to recalibrate growth and pH homeostasis.Frontiers in plant science · 2023Article
- Iron sensing in plants.Frontiers in plant science · 2023Review
- Comprehensive Survey of ChIP-Seq Datasets to Identify Candidate Iron Homeostasis Genes Regulated by Chromatin Modifications.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Editorial: Role of shoot-derived signals in root responses to environmental changes.Frontiers in plant science · 2023Article
- pH sensors in the plant apoplast: aFrontiers in plant science · 2023Article
- Black sheep, dark horses, and colorful dogs: a review on the current state of the Gene Ontology with respect to iron homeostasis inFrontiers in plant science · 2023Review
- Iron uptake, signaling, and sensing in plants.Plant communications · 2022Review
- Systemic Regulation of Iron Acquisition by Arabidopsis in Environments with Heterogeneous Iron Distributions.Plant & cell physiology · 2022Article
- A Quick Method to Quantify Iron inBio-protocol · 2022Article
- A shoot derived long distance iron signal may act upstream of the IMA peptides in the regulation of Fe deficiency responses inFrontiers in plant science · 2022Article
- Chalky pH and Fe deficiency? IRONMAN to the rescue.Plant physiology · 2021Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron (Fe) is an essential mineral element that governs the composition of natural plant communities and limits crop yield in agricultural ecosystems due to its extremely low availability in most soils, particularly at alkaline pH. To extract sufficient Fe from the soil under such conditions, some plants, including Arabidopsis (Arabidopsis thaliana), secrete Fe-mobilizing phenylpropanoids, which mobilize sparingly soluble Fe hydroxides by reduction and chelation. We show here that ectopic expression of the peptides IRONMAN (IMA1) and IMA2 improves growth on calcareous soil by inducing biosynthesis and secretion of the catecholic coumarin 7,8-dihydroxy-6-methoxycoumarin (fraxetin) via increased expression of MYB72 and SCOPOLETIN 8-HYDROXYLASE, a response that is strictly dependent on elevated environmental pH (pHe). By contrast, transcription of the cytochrome P450 family protein CYP82C4, catalyzing the subsequent hydroxylation of fraxetin to sideretin, which forms less stable complexes with iron, was strongly repressed under such conditions. We concluded that IMA peptides regulate processes supporting Fe uptake at both acidic and elevated pH by controlling gene expression upstream of or in concert with a putative pHe signal, adapting the plant to prevailing edaphic conditions. This regulatory pattern confers tolerance to calcareous soils by extending the pH range in which Fe can be efficiently absorbed from the soil. Our results further suggest that pHe calibrates the activities of components of the Fe deficiency response, accentuating processes that are most efficient under the prevailing conditions. Altering the expression of IMA peptides provides a route for generating plants adapted to calcareous soils.
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