ArticlePlant physiology2021
Recycling of the major thylakoid lipid MGDG and its role in lipid homeostasis in Chlamydomonas reinhardtii.
Article in Plant physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 29 citations in OpenAlex.
- Membrane lipid remodeling under salt stress is associated with salt tolerance in lettuce.BMC plant biology · 2026Article
- Integrated transcriptomic, metabolomic and lipidomic analyses uncover the crucial roles of lipid metabolism pathways in oat (Avena sativa) responses to heat stress.BMC genomics · 2025Article
- Chromosome-level genomes of two Bracteacoccaceae highlight adaptations to biocrusts.Nature communications · 2025Article
- Monogalactosyldiacylglycerol synthase isoforms play diverse roles inside and outside the diatom plastid.The Plant cell · 2024Article
- Establishment of Saccharomyces cerevisiae as a cell factory for efficient de novo production of monogalactosyldiacylglycerol.Biotechnology for biofuels and bioproducts · 2024Article
- OsMGD1-Mediated Membrane Lipid Remodeling Improves Salt Tolerance in Rice.Plants (Basel, Switzerland) · 2024Article
- Development of a high-performance thin-layer chromatography-based method for targeted glycerolipidome profiling of microalgae.Analytical and bioanalytical chemistry · 2024Article
- Deacylation of galactolipids decomposes photosystem II dimers to enhance degradation of damaged D1 protein.Plant physiology · 2023Article
- Do betaine lipids replace phosphatidylcholine as fatty acid editing hubs in microalgae?Frontiers in plant science · 2023Review
- Inhibition of monogalactosyldiacylglycerol synthesis by down-regulation of MGD1 leads to membrane lipid remodeling and enhanced triacylglycerol biosynthesis in Chlamydomonas reinhardtii.Biotechnology for biofuels and bioproducts · 2022Article
- 13C-labeling reveals how membrane lipid components contribute to triacylglycerol accumulation in Chlamydomonas.Plant physiology · 2022Article
- Lipid turnover and SQUAMOSA promoter-binding proteins mediate variation in fatty acid desaturation under early nitrogen deprivation revealed by lipidomic and transcriptomic analyses inFrontiers in plant science · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Monogalactosyldiacylglycerol (MGDG), the most abundant lipid in thylakoid membranes, is involved in photosynthesis and chloroplast development. MGDG lipase has an important role in lipid remodeling in Chlamydomonas reinhardtii. However, the process related to turnover of the lysogalactolipid that results from MGDG degradation, monogalactosylmonoacylglycerol (MGMG), remains to be clarified. Here we identified a homolog of Arabidopsis thaliana lysophosphatidylcholine acyltransferase (LPCAT) and characterized two independent knockdown (KD) alleles in C. reinhardtii. The enzyme designated as C. reinhardtiiLysolipid Acyltransferase 1 (CrLAT1) has a conserved membrane-bound O-acyl transferase domain. LPCAT from Arabidopsis has a key role in deacylation of phosphatidylcholine (PC). Chlamydomonas reinhardtii, however, lacks PC, and thus we hypothesized that CrLAT1 has some other important function in major lipid flow in this organism. In the CrLAT1 KD mutants, the amount of MGMG was increased, but triacylglycerols (TAGs) were decreased. The proportion of more saturated 18:1 (9) MGDG was lower in the KD mutants than in their parental strain, CC-4533. In contrast, the proportion of MGMG has decreased in the CrLAT1 overexpression (OE) mutants, and the proportion of 18:1 (9) MGDG was higher in the OE mutants than in the empty vector control cells. Thus, CrLAT1 is involved in the recycling of MGDG in the chloroplast and maintains lipid homeostasis in C. reinhardtii.
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