Trial reportEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery2022
Long-term survival after coronary bypass surgery with multiple versus single arterial grafts.
Trial report in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SYNTAX Study: SYNergy Between PCI With TAXUS and Cardiac Surgery
Synergy Between PCI With TAXUS and Cardiac Surgery: SYNTAX Extended Survival
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Differences in long-term survival outcomes after coronary artery bypass grafting using single vs multiple arterial grafts: a meta-analysis with reconstructed time-to-event data and subgroup analyses.General thoracic and cardiovascular surgery · 2023Pooled it
- Bypass graft design assisted by virtual reality simulation in multi-vessel coronary artery bypass grafting.General thoracic and cardiovascular surgery · 2026Article
- Bayesian Network Meta-Analysis of Long-Term Survival: Single vs Multiple vs Total Arterial Coronary Bypass Grafting.JACC. Advances · 2026Article
- Reply: Signals vs Causation: What Observational Data Show and What They Cannot Prove.JACC. Advances · 2026Article
- Signals vs Causation: What Observational Data Show and What They Cannot Prove.JACC. Advances · 2026Article
- Coronary Artery Bypass Grafting: A Review of Short- and Long-Term Outcomes.The International journal of angiology : official publication of the International College of Angiology, Inc · 2025Review
- Discharge prescription patterns in multiarterial versus single-arterial coronary artery bypass grafting: A regional multicenter cohort analysis.JTCVS open · 2025Article
- Safety, efficacy, and postoperative pulmonary function recovery of uniportal and multiportal thoracoscopic lung segmentectomy.Journal of thoracic disease · 2025Article
- Coronary artery bypass grafting using both internal mammary arteries-a safe concept for surgical training.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Long-term outcomes of women compared to men after off-pump coronary artery bypass grafting-a propensity-matched analysis.Indian journal of thoracic and cardiovascular surgery · 2025Article
- Comparison of multiple arterial grafts vs. single arterial graft in coronary artery bypass surgery: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Article
- Comparison in trends and outcomes of multiple vs. single arterial coronary bypass graft surgery.Frontiers in cardiovascular medicine · 2025Article
- Multivessel Coronary Disease and Severe Atherosclerotic Aorta: Real-World Experience.Medicina (Kaunas, Lithuania) · 2023Observational
- Multi-Omics Profiling of Human Endothelial Cells from the Coronary Artery and Internal Thoracic Artery Reveals Molecular but Not Functional Heterogeneity.International journal of molecular sciences · 2023Article
- The Feasibility and Early Results of Multivessel Minimally Invasive Coronary Artery Bypass Grafting for All Comers.Journal of clinical medicine · 2023Article
- Long-Term Survival of Multiple Versus Single Arterial Coronary Bypass Grafting in Elderly Patients.Journal of clinical medicine · 2023Article
- Multiple arterial versus single arterial grafting in patients with diabetes undergoing coronary artery bypass surgery.JTCVS open · 2023Article
- Risk factors for major adverse cardiovascular events after coronary artery bypass grafting using radial artery grafts.Frontiers in cardiovascular medicine · 2023Article
- Reply to Royse et al.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2022Article
- Prognostic significance of postoperative loss of skeletal muscle mass in patients underwent coronary artery bypass grafting.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
15 authors at 11 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study sought to evaluate the long-term differences in survival between multiple arterial grafts (MAG) and single arterial grafts (SAG) in patients who underwent coronary artery bypass grafting (CABG) in the SYNTAX study.
methodsThe present analysis included the randomized and registry-treated CABG patients (n = 1509) from the SYNTAX Extended Survival study (SYNTAXES). Patients with only venous (n = 42) or synthetic grafts (n = 1) were excluded. The primary end point was all-cause death at the longest follow-up. Multivariable Cox regression was used to adjust for differences in baseline characteristics. Sensitivity analysis using propensity matching with inverse probability for treatment weights was performed.
resultsOf the 1466 included patients, 465 (31.7%) received MAG and 1001 (68.3%) SAG. Patients receiving MAG were younger and at lower risk. At the longest follow-up of 12.6 years, all-cause death occurred in 23.6% of MAG and 40.0% of SAG patients [adjusted hazard ratio (HR) 0.74, 95% confidence interval (CI) (0.55-0.98); P = 0.038], which was confirmed by sensitivity analysis. MAG in patients with the three-vessel disease was associated with significant lower unadjusted and adjusted all-cause death at 12.6 years [adjusted HR 0.65, 95% CI (0.44-0.97); P = 0.033]. In contrast, no significance was observed after risk adjustment in patients with the left main disease, with and without diabetes, or among SYNTAX score tertiles.
conclusionsIn the present post hoc analysis of all-comers patients from the SYNTAX trial, MAG resulted in markedly lower all-cause death at 12.6-year follow-up compared to a SAG strategy. Hence, this striking long-term survival benefit of MAG over SAG encourages more extensive use of multiple arterial grafting in selected patients with reasonable life expectancy.
trial registrationSYNTAXES ClinicalTrials.gov reference: NCT03417050; SYNTAX ClinicalTrials.gov reference: NCT00114972.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.