Evidence map›Paper›PMID 34617883›Full record

ArticleParasite (Paris, France)2021

Effect of household bleach on the structure of the sporocyst wall of Toxoplasma gondii.

Aurélien Dumètre, Jitender P Dubey, David J P Ferguson

Open access · goldAbstract read
In one paragraph

Article in Parasite (Paris, France), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Insights into the Structural and Proteomic Changes inAnimals : an open access journal from MDPI · 2025
    Article
  2. Proteomic Analysis of FractionatedInternational journal of molecular sciences · 2023
    Article
  3. Article
  4. Hastening Progress inMicroorganisms · 2022
    Article
  5. Seropositivity of Anti-Tropical medicine and infectious disease · 2022
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Aurélien DumètreAix Marseille Univ, IRD, AP-HM, SSA, VITROME, 13005 Marseille, France - IHU-Méditerranée Infection, 13005 Marseille, France.ORCID 0000-0001-5494-6326
Jitender P DubeyUnited States Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Animal Parasitic Diseases Laboratory, Building 1001, Beltsville, 20705-2350 MD, United States.
David J P FergusonDepartment of Biological and Medical Sciences, Faculty of Health and Life Science, Oxford Brookes University, OX3 0FL Oxford, United Kingdom - Nuffield Department of Clinical Laboratory Science, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, United Kingdom.
Agricultural Research Service · USAix-Marseille Université · FROxford Brookes University · GB

Funding

Conseil Régional Provence-Alpes-Côte d'Azur 2014-02623
6 · The paper itself

Abstract

Toxoplasma gondii oocysts are responsible for food- and water-borne infections in humans worldwide. They are resistant to common chemical disinfectants, including chlorinated products, presumably due to the structure and molecular nature of the oocyst wall but also the sporocyst wall. In this study, we used fluorescence microscopy and transmission electron microscopy to characterise the structure of both the oocyst and sporocyst walls, exposed to household bleach. Bleach removed the outer layer of the oocyst wall and the outer layer of the wall of sporocysts exposed due to rupture of the oocyst wall. The loss of the outer sporocyst wall layer was associated with a decrease in its autofluorescence, which can be linked to the degradation of dityrosine cross-link proteins, and loss of Maclura pomifera lectin-reactive glycoproteins. This study suggests that the inner layers of the oocyst and sporocyst walls are the main structures responsible for the resistance of the parasite to household bleach.

Indexed as

ToxoplasmaGlycoproteinsMicroscopy, FluorescenceOocystsSodium HypochloriteGlycoproteinsSodium HypochloriteBleachOocystResistanceSporocystToxoplasma gondiiWall

Identifiers

PMID34617883
PMCPMC8496345
OpenAlexW3203520175

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.