Evidence map›Paper›PMID 34617636›Full record

ReviewJournal of clinical laboratory analysis2021

CircRNAs: a family number of miRNA regulatory transcriptome in laryngeal carcinoma.

Limin Miao, Guanying Feng, Hua Yuan

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Limin MiaoDepartment of Geriatric Dentistry, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0003-4308-3064
Guanying FengJiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Hua YuanJiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Nanjing Medical University · CN

Funding

National Natural Science Foundation of China grants 81803322
6 · The paper itself

Abstract

Laryngeal carcinoma (LC) is a common head and neck cancer, which is the result of mutational changes due to gene dysregulation and etiological factors such as tobacco and smoking. A large number of patients received a poor prognosis due to diagnosis at an advanced stage. This highlights the need for definitive, early, and efficient diagnoses. With rapid development of high-throughput sequencing, circular RNA (circRNA) has been reported to play a pivotal role in cancer. CircRNA functions as a microRNA (miRNA) sponge in the regulation of mRNA expression, forming circRNA-miRNA regulatory axis. In this review, we described the axis in LC. The result indicated that CDR1as, hsa_circ_0042823, hsa_circ_0023028, circPARD3, hsa_circ_103862, hsa_circ_0000218, circMYLK, circCORO1C, hsa_circ_100290, circ-CCND1, hsa_circ_0057481, circFLAN, and circRASSF2 expressed higher in LC, whereas, hsa_circ_0036722 and hsa_circ_0042666 expressed lower. The circRNAs regulated the target genes by sponging miRNAs and contributed to the pathogenesis of LC.

Indexed as

Laryngeal NeoplasmsMicroRNAsRNA, CircularTranscriptomeCarcinomaFemaleGene Expression Regulation, NeoplasticHumansMaleMicroRNAsRNA, CircularcircRNAcircRNA-miRNA axislaryngeal carcinomamiRNA spongeregulation

Identifiers

PMID34617636
PMCPMC8605118
OpenAlexW3204907609

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.