Evidence map›Paper›PMID 34617526›Full record

ArticleBiomaterials science2021

Decellularised extracellular matrix decorated PCL PolyHIPE scaffolds for enhanced cellular activity, integration and angiogenesis.

Serkan Dikici, Betül Aldemir Dikici, Sheila MacNeil, Frederik Claeyssens

Abstract read
In one paragraph

Article in Biomaterials science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. ACS applied materials & interfaces · 2023
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Developing Wound Dressings Using 2-deoxy-International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Serkan DikiciDepartment of Bioengineering, Izmir Institute of Technology, Izmir, 35430, Turkey. serkandikici@iyte.edu.tr.ORCID http://orcid.org/0000-0001-9933-5254
Betül Aldemir DikiciDepartment of Bioengineering, Izmir Institute of Technology, Izmir, 35430, Turkey. serkandikici@iyte.edu.tr.ORCID http://orcid.org/0000-0002-5516-469X
Sheila MacNeilDepartment of Materials Science and Engineering, University of Sheffield, Kroto Research Institute, Sheffield, S3 7HQ, UK. f.claeyssens@sheffield.ac.uk.
Frederik ClaeyssensDepartment of Materials Science and Engineering, University of Sheffield, Kroto Research Institute, Sheffield, S3 7HQ, UK. f.claeyssens@sheffield.ac.uk.

Funding

Medical Research Council MR/L012669/1
6 · The paper itself

Abstract

Wound healing involves a complex series of events where cell-cell and cell-extracellular matrix (ECM) interactions play a key role. Wounding can be simple, such as the loss of the epithelial integrity, or deeper and more complex, reaching to subcutaneous tissues, including blood vessels, muscles and nerves. Rapid neovascularisation of the wounded area is crucial for wound healing as it has a key role in supplying oxygen and nutrients during the highly demanding proliferative phase and transmigration of inflammatory cells to the wound area. One approach to circumvent delayed neovascularisation is the exogenous use of pro-angiogenic factors, which is expensive, highly dose-dependent, and the delivery of them requires a very well-controlled system to avoid leaky, highly permeable and haemorrhagic blood vessel formation. In this study, we decorated polycaprolactone (PCL)-based polymerised high internal phase emulsion (PolyHIPE) scaffolds with fibroblast-derived ECM to assess fibroblast, endothelial cell and keratinocyte activity

Indexed as

Extracellular MatrixNeovascularization, PhysiologicAnimalsChorioallantoic MembranePolymersStyrenespolyHIPEPolymersStyrenes

Identifiers

PMID34617526
PMCPMC8547328

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.