Evidence map›Paper›PMID 34617511›Full record

ArticleeLife2021

The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health.

Qi Yan Ang, Diana L Alba, Vaibhav Upadhyay, Jordan E Bisanz, Jingwei Cai, Ho Lim Lee, Eliseo Barajas, Grace Wei, Cecilia Noecker, Andrew D Patterson and 2 more

Abstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Efficacy and Safety ofFrontiers in endocrinology · 2021
    Trial
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qi Yan Ang *Department of Microbiology and Immunology, G.W. Hooper Research Foundation, San Francisco, United States.ORCID 0000-0002-9788-1283
Diana L Alba *Diabetes Center, University of California San Francisco, San Francisco, United States.ORCID 0000-0002-1398-9861
Vaibhav Upadhyay *Department of Microbiology and Immunology, G.W. Hooper Research Foundation, San Francisco, United States.ORCID 0000-0002-7652-1043
Jordan E BisanzDepartment of Microbiology and Immunology, G.W. Hooper Research Foundation, San Francisco, United States.ORCID 0000-0002-8649-1706
Jingwei CaiCenter for Molecular Toxicology and Carcinogenesis, Department of Veterinary & Biomedical Sciences, Pennsylvania State University, College Park, United States.
Ho Lim LeeDiabetes Center, University of California San Francisco, San Francisco, United States.
Eliseo BarajasDiabetes Center, University of California San Francisco, San Francisco, United States.
Grace WeiDiabetes Center, University of California San Francisco, San Francisco, United States.
Cecilia NoeckerDepartment of Microbiology and Immunology, G.W. Hooper Research Foundation, San Francisco, United States.
Andrew D PattersonCenter for Molecular Toxicology and Carcinogenesis, Department of Veterinary & Biomedical Sciences, Pennsylvania State University, College Park, United States.
Suneil K KoliwadDiabetes Center, University of California San Francisco, San Francisco, United States.
Peter J TurnbaughDepartment of Microbiology and Immunology, G.W. Hooper Research Foundation, San Francisco, United States.ORCID 0000-0002-0888-2875

Funding

MUTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007185 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David J Erle, LAURENCE HUANG · 1985 to 2026
$24.6M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Predicting and preventing drug metabolism by the human gut microbiomeR01HL122593 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Peter James Turnbaugh · 2016 to 2026
$5.7M
Employing the gut microbiome to accelerate effective initiation of rheumatoid arthritis therapyR01AR074500 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Renuka Rajendra Nayak, Jose U. Scher · 2019 to 2026
$4.1M
Host-microbiome interactions shape the metabolic effects of ketogenic dietsR01DK114034 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TURNBAUGH, PETER JAMES · 2020 to 2024
$2.5M
NHLBI NIH HHS R01 HL122593NHLBI NIH HHS T32 HL007185NIAMS NIH HHS R01 AR074500NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01DK11230401NIDDK NIH HHS R01 DK114034NIH HHS R01DK11230403S1
6 · The paper itself

Abstract

East Asians (EAs) experience worse metabolic health outcomes compared to other ethnic groups at lower body mass indices; however, the potential role of the gut microbiota in contributing to these health disparities remains unknown. We conducted a multi-omic study of 46 lean and obese East Asian and White participants living in the San Francisco Bay Area, revealing marked differences between ethnic groups in bacterial richness and community structure. White individuals were enriched for the mucin-degrading

Indexed as

Gastrointestinal MicrobiomeMetagenomeAsia, EasternBacteriaBacterial Physiological PhenomenaCaliforniaFecesMetabolismMetagenomicsSan Franciscobiogeographyethnicityhumanhuman gut microbiomeinfectious diseasemetabolic syndromemicrobiologymousemulti-omicsobesity

Identifiers

PMID34617511
PMCPMC8612731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.