Evidence map›Paper›PMID 34617391›Full record

ArticleInternational wound journal2022

Fractal analysis of rat dermal tissue in the different injury states.

Haisong Xu, Jingde Zhang, Yuzhi Jiang, Shuliang Lu, Yiwen Niu, Jiaoyun Dong, Shuwen Jin, Fei Song, Xiaozan Cao, Chun Qing and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International wound journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Haisong XuShanghai Burns Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Jingde ZhangThe department of plastic surgery, Changhai Hospital, the Second Military Medical University, Shanghai, China.
Yuzhi JiangShanghai Burns Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.ORCID https://orcid.org/0000-0002-8205-4947
Shuliang LuShanghai Burns Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Yiwen NiuShanghai Burns Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Jiaoyun DongShanghai Burns Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Shuwen JinShanghai Burns Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Fei SongShanghai Burns Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Xiaozan CaoShanghai Burns Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Chun QingShanghai Burns Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Ming TianShanghai Burns Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Yingkai LiuShanghai Burns Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Shanghai Jiao Tong University · CNSecond Military Medical University · CN

Funding

National Natural Science Foundation of China 30872685National Natural Science Foundation of China 81272110
6 · The paper itself

Abstract

Scar formation and chronic ulcers can develop following a skin injury. They are the result of the over- or underproduction of collagen. It is very important to evaluate the quality and quantity of the collagen that is produced during wound healing, especially with respect to its structure, as these factors are very important to a complicated outcome. However, there is no standard way to quantitatively analyse dermal collagen. As prior work characterised some potentially fractal properties of collagen, it was hypothesised that collagen structure could be evaluated with fractal dimension analysis. Small-angle X-ray scattering technology (SAXS) was used to evaluate the dermis of rats exposed to graft harvest, burn, and diabetic pathologic states. It was found that almost all collagen structures could be quantitatively measured with fractal dimension analysis. Further, there were significant differences in the three-dimensional (3-D) structure of normal collagen versus that measured in pathologic tissues. There was a significant difference in the 3-D structure of collagen at different stages of healing. The findings of this work suggest that fractal analysis is a good tool for wound healing analysis, and that quantitative collagen analysis is very useful for assessing the structure of dermal collagen.

Indexed as

BurnsDermisAnimalsCollagenFractalsRatsScattering, Small AngleX-Ray DiffractionCollagenburnscollagen structurediabetesfractal dimensionquantitative analysiswound model

Identifiers

PMID34617391
PMCPMC9284641
OpenAlexW3203771909

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.