Evidence map›Paper›PMID 34617373›Full record

Trial reportEuropean journal of heart failure2022

Effects of an outpatient intervention comprising nurse-led non-invasive assessments, telemedicine support and remote cardiologists' decisions in patients with heart failure (AMULET study): a randomised controlled trial.

Paweł Krzesiński, Ewa A Jankowska, Janusz Siebert, Agata Galas, Katarzyna Piotrowicz, Adam Stańczyk, Paweł Siwołowski, Piotr Gutknecht, Paweł Chrom, Piotr Murawski and 5 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07490470 (A Nurse-Led, Multidisciplinary mHealth Program to Manage Heart Failure During the Vulnerable Post-Discharge Period), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07490470 nacompletednot on this map

A Nurse-Led, Multidisciplinary mHealth Program to Manage Heart Failure During the Vulnerable Post-Discharge Period

TypeinterventionalSponsorPeking University First HospitalRan2022 to 2025Enrolled104ConditionsHeart FailureArmsNurse-Led mHealth Multidisciplinary Management, Routine Outpatient Follow-Up
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Which heart failure patients benefit most from non-invasive telemedicine? An overview of current evidence and future directions.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2024
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. VA Home Telehealth Program for Initiating and Optimizing Heart Failure Guideline-Directed Medical Therapy.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2023
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Paweł KrzesińskiDepartment of Cardiology and Internal Diseases, Military Institute of Medicine, Warsaw, Poland.
Ewa A JankowskaDepartment of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Janusz SiebertUniversity Center for Cardiology, Gdansk, Poland.
Agata GalasDepartment of Cardiology and Internal Diseases, Military Institute of Medicine, Warsaw, Poland.
Katarzyna PiotrowiczDepartment of Cardiology and Internal Diseases, Military Institute of Medicine, Warsaw, Poland.
Adam StańczykDepartment of Cardiology and Internal Diseases, Military Institute of Medicine, Warsaw, Poland.
Paweł SiwołowskiDepartment of Cardiology, Centre for Heart Diseases, 4th Military Hospital, Wroclaw, Poland.
Piotr GutknechtDepartment of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Paweł ChromDepartment of Cardiology and Internal Diseases, Military Institute of Medicine, Warsaw, Poland.
Piotr MurawskiDepartment of Informatics, Military Institute of Medicine, Warsaw, Poland.
Andrzej WalczakSoftware Engineering Department, Cybernetics Faculty, Military University of Technology, Warsaw, Poland.
Dominika SzalewskaClinic of Rehabilitation Medicine, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland.
Waldemar BanasiakDepartment of Cardiology, Centre for Heart Diseases, 4th Military Hospital, Wroclaw, Poland.
Piotr PonikowskiDepartment of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Grzegorz GielerakDepartment of Cardiology and Internal Diseases, Military Institute of Medicine, Warsaw, Poland.
Wojskowy Instytut Medycyny Lotniczej · PLWroclaw Medical University · PLGdańsk Medical University · PLMilitary Hospital · PKMilitary University of Technology in Warsaw · PLNational Academy of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimPrevention of heart failure (HF) hospitalisations and deaths constitutes a major therapeutic aim in patients with HF. The role of telemedicine in this context remains equivocal. We investigated whether an outpatient telecare based on nurse-led non-invasive assessments supporting remote therapeutic decisions (AMULET telecare) could improve clinical outcomes in patients after an episode of acute HF during 12-month follow-up. METHODS AND

resultsIn this prospective randomised controlled trial, patients with HF and left ventricular ejection fraction (LVEF) ≤49%, after an episode of acute HF within the last 6 months, were randomly assigned to receive either an outpatient telecare based on nurse-led non-invasive assessments (n = 300) (AMULET model) or standard care (n = 305). The primary composite outcome of unplanned HF hospitalisation or cardiovascular death occurred in 51 (17.1%) patients in the telecare group and 73 (23.9%) patients in the standard care group up to 12 months after randomization [hazard ratio (HR) 0.69, 95% confidence interval (CI) 0.48-0.99; P = 0.044]. The implementation of AMULET telecare, as compared to standard care, reduced the risk of first unplanned HF hospitalisation (HR 0.62, 95% CI 0.42-0.91; P = 0.015) as well as the risk of total unplanned HF hospitalisations (HR 0.64, 95% CI 0.41-0.99; P = 0.044).There was no difference in cardiovascular mortality between the study groups (HR 1.03, 95% CI 0.54-1.67; P = 0.930).

conclusionsAMULET telecare as compared to standard care significantly reduced the risk of HF hospitalisation or cardiovascular death during 12-month follow-up among patients with HF and LVEF ≤49% after an episode of acute HF.

Indexed as

CardiologistsHeart FailureTelemedicineHospitalizationHumansNurse's RoleOutpatientsProspective StudiesStroke VolumeVentricular Function, LeftAmbulatory careHeart failureHeart failure hospitalisationTelecare

Identifiers

PMID34617373
PMCPMC9293217
OpenAlexW3202780604

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.