Evidence map›Paper›PMID 34617367›Full record

ArticleJournal of evaluation in clinical practice2022

From "getting things right" to "getting things right now": Developing COVID-19 guidance under time pressure and knowledge uncertainty.

Marjolein Moleman, Fergus Macbeth, Sietse Wieringa, Frode Forland, Beth Shaw, Teun Zuiderent-Jerak

Abstract read
In one paragraph

Article in Journal of evaluation in clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marjolein MolemanAthena Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-5289-2341
Fergus MacbethCentre for Trials Research, Cardiff University, Cardiff, UK.
Sietse WieringaNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Frode ForlandDivision for Infectious Diseases and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
Beth ShawOregon Health & Science University, Portland, Oregon, USA.
Teun Zuiderent-JerakAthena Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-3008-1297

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAt the start of the COVID-19 pandemic, guidance was needed more than ever to direct frontline healthcare and national containment strategies. Rigorous guidance based on robust research was compromised by the emergence of the pandemic and the urgency of need for guidance. Rather than aiming to "get guidance right", guidance developers needed to "get guidance right now".

aimTo examine how guidance developers have responded to the need for credible guidance at the start of the COVID-19 pandemic.

methodsAn exploratory mixed-methods study was conducted among guidance developers. A web-based survey and follow-up interviews were used to examine the most pertinent challenges in developing COVID-19 guidance, strategies used to address these, and perspectives on the implications of the COVID-19 pandemic on future guidance development.

resultsThe survey was completed by 46 guidance developers. Survey findings showed that conventional methods of guidance development were largely unsuited for COVID-19 guidance, with 80% (n = 37) of respondents resorting to other methods. From the survey and five follow-up interviews, two themes were identified to bolster the credibility of guidance in a setting of extreme uncertainty: (1) strengthening end-user involvement and (2) conjoining evidence review and recommendation formulation. 70% (n = 32) of survey respondents foresaw possible changes in future guidance production, most notably shortening development time, by reconsidering how to balance between rigour and speed for different types of questions.

conclusion"Getting guidance right" and "getting guidance right now" are not opposites, rather uncertainties are always part of guidance development and require guidance developers to balance scientific robustness with usability, acceptability, adequacy and contingency. This crisis points to the need to acknowledge uncertainties of scientific evidence more explicitly and points to mechanisms to live with such uncertainty, thus extending guidance development methods and processes more widely.

Indexed as

COVID-19Delivery of Health CareHumansPandemicsSARS-CoV-2Uncertaintyclinical guidelinesepistemologyevidence-based medicinehealthcarepublic health

Identifiers

PMID34617367
PMCPMC8657322

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.