Evidence map›Paper›PMID 34617212›Full record

ArticleEnvironmental science and pollution research international2022

The neonatal PROC gene rs1799809 polymorphism modifies the association between prenatal air pollutants exposure and PROC promoter methylation.

Zhiyuan Li, Meng Yang, Leizhen Duan, Yongxiang Gong, Hongxia Xia, Francis-Kojo Afrim, Hui Huang, Xiaoxue Liu, Fangfang Yu, Yawei Zhang and 2 more

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Zhiyuan LiDepartment of Environmental Health, School of Public Health, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan, 450001, People's Republic of China.
Meng YangDepartment of Environmental Health, School of Public Health, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan, 450001, People's Republic of China.
Leizhen DuanDepartment of Environmental Health, School of Public Health, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan, 450001, People's Republic of China.
Yongxiang GongDepartment of Environmental Health, School of Public Health, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan, 450001, People's Republic of China.
Hongxia XiaDepartment of Environmental Health, School of Public Health, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan, 450001, People's Republic of China.
Francis-Kojo AfrimDepartment of Environmental Health, School of Public Health, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan, 450001, People's Republic of China.
Hui HuangDepartment of Environmental Health, School of Public Health, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan, 450001, People's Republic of China.
Xiaoxue LiuDepartment of Environmental Health, School of Public Health, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan, 450001, People's Republic of China.
Fangfang YuDepartment of Environmental Health, School of Public Health, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan, 450001, People's Republic of China.
Yawei ZhangDepartment of Environment Health Science, Yale University School of Public Health, New Haven, CT, USA.
Yue BaDepartment of Environmental Health, School of Public Health, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan, 450001, People's Republic of China.
Guoyu ZhouDepartment of Environmental Health, School of Public Health, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan, 450001, People's Republic of China. zhouguoyu@zzu.edu.cn.ORCID http://orcid.org/0000-0003-0779-7123
Zhengzhou University · CNYale University · US

Funding

national natural science foundation of china 81673116national natural science foundation of china 81972981national natural science foundation of china 82003401opening foundation of national health commission key laboratory of birth defects prevention ZD202001
6 · The paper itself

Abstract

Prenatal air pollution, protein C (PROC) gene abnormal methylation, and genetic mutation can cause a series of neonatal diseases, but the complex relationship between them remains unclear. Here, we recruited 552 mothers and their own babies during January 2010-January 2012 in Zhengzhou to explore such association. The air pollutant data was obtained from the Environmental Monitoring Stations. The rs1799809 genotype and the methylation levels at the promoter region of PROC in genomic DNA samples were detected respectively by TaqMan probe and quantitative methylation specific PCR using real-time PCR system. The results show that the levels of neonatal PROC methylation were negatively associated with concentrations of NO

Indexed as

Air PollutantsAir PollutionChinaFemaleHumansInfantInfant, NewbornMaternal ExposureMethylationParticulate MatterPregnancyPromoter Regions, GeneticProtein CAir PollutantsParticulate MatterProtein CAir pollutionDNA methylationGenotypesNewbornPregnancyProtein C gene

Identifiers

PMID34617212
OpenAlexW3204457910

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.