ReviewGenetica2022
Using phenotypic plasticity to understand the structure and evolution of the genotype-phenotype map.
Review in Genetica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Mild Warming Induces Divergent Plastic Responses in Gene Expression Among Populations of a Temperate Butterfly.Molecular ecology · 2026Article
- Embryonic Hormetic Priming Modulates Later-Life Thermal Tolerance.Ecology and evolution · 2026Article
- Genotype by Environment Interactions in Gene Regulation Underlie the Response to Soil Drying in the Model Grass Brachypodium distachyon.Molecular biology and evolution · 2025Article
- Plastic sex-trait modulation by differential gene expression according to social environment in male red deer.BMC genomics · 2025Article
- Impacts of limits to adaptation on population and community persistence in a changing environment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Review
- Beyond genes-for-behaviour: The potential for genomics to resolve long-standing questions in avian brood parasitism.Ecology and evolution · 2024Review
- Facilitation of Evolution by Plasticity Scales with Phenotypic Complexity.Animals : an open access journal from MDPI · 2024Article
- Utilizing developmental dynamics for evolutionary prediction and control.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Plasticity and associated epigenetic mechanisms play a role in thermal evolution during range expansion.Evolution letters · 2024Article
- Sexual conflict, heterochrony and tissue specificity as evolutionary problems of adaptive plasticity in development.Proceedings. Biological sciences · 2023Review
- Is intraspecific trait differentiation inPlant diversity · 2023Article
- Evolutionary Change in Gut Specification inJournal of developmental biology · 2023Review
- Phenotypic plasticity evolves at multiple biological levels in response to environmental predictability in a long-term experiment with a halotolerant microalga.PLoS biology · 2023Article
- Computational modelling of plasticity-led evolution.Biophysical reviews · 2022Review
- Plasticity across levels: Relating epigenomic, transcriptomic, and phenotypic responses to osmotic stress in a halotolerant microalga.Molecular ecology · 2022Article
- Why study plasticity in multiple traits? New hypotheses for how phenotypically plastic traits interact during development and selection.Evolution; international journal of organic evolution · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Deciphering the genotype-phenotype map necessitates relating variation at the genetic level to variation at the phenotypic level. This endeavour is inherently limited by the availability of standing genetic variation, the rate of spontaneous mutation to novo genetic variants, and possible biases associated with induced mutagenesis. An interesting alternative is to instead rely on the environment as a source of variation. Many phenotypic traits change plastically in response to the environment, and these changes are generally underlain by changes in gene expression. Relating gene expression plasticity to the phenotypic plasticity of more integrated organismal traits thus provides useful information about which genes influence the development and expression of which traits, even in the absence of genetic variation. We here appraise the prospects and limits of such an environment-for-gene substitution for investigating the genotype-phenotype map. We review models of gene regulatory networks, and discuss the different ways in which they can incorporate the environment to mechanistically model phenotypic plasticity and its evolution. We suggest that substantial progress can be made in deciphering this genotype-environment-phenotype map, by connecting theory on gene regulatory network to empirical patterns of gene co-expression, and by more explicitly relating gene expression to the expression and development of phenotypes, both theoretically and empirically.
Indexed as
Identifiers
34617196What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.