Evidence map›Paper›PMID 34617151›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2022

The pattern of incident fractures according to fracture site in people with T1D.

N H Rasmussen, C Sarodnik, S P G Bours, N C Schaper, P C Souverein, M H Jensen, J H M Driessen, J P W van den Bergh, P Vestergaard

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

N H RasmussenSteno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark. nicklas.rasmussen@rn.dk.ORCID http://orcid.org/0000-0002-3880-3058
C SarodnikNUTRIM Research School, Maastricht University, Maastricht, The Netherlands.
S P G BoursDepartment of Internal Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.
N C SchaperDepartment of Internal Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.
P C SouvereinDivision of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
M H JensenSteno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark.
J H M DriessenNUTRIM Research School, Maastricht University, Maastricht, The Netherlands.
J P W van den BerghNUTRIM Research School, Maastricht University, Maastricht, The Netherlands.
P VestergaardSteno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark.

Funding

Novo Nordisk Fonden NNF18OC0052064
6 · The paper itself

Abstract

Higher incidences of fractures are seen in people with type 1 diabetes (T1D), but knowledge on different fracture sites is sparse. We found a higher incidence mainly for distal fracture sites in people with T1D compared to controls. It must be further studied which fractures attributed to the higher incidence rates (IRs) at specific sites.

introductionPeople with T1D have a higher incidence of fractures compared to the general population. However, sparse knowledge exists on the incidence rates of individual fracture sites. Therefore, we examined the incidence of various fracture sites in people with newly treated T1D compared to matched controls.

methodsAll people from the UK Clinical Practice Research Datalink GOLD (1987-2017), of all ages with a T1D diagnosis code (n = 6381), were included. People with T1D were matched by year of birth, sex, and practice to controls (n = 6381). Fracture IRs and incidence rate ratios (IRRs) were calculated. Analyses were stratified by fracture site and sex.

resultsThe IR of all fractures was significantly higher in people with T1D compared to controls (IRR: 1.39 (CI95%: 1.24-1.55)). Compared to controls, the IRR for people with T1D was higher for several fracture sites including carpal (IRR: 1.41 (CI95%: 1.14-1.75)), clavicle (IRR: 2.10 (CI95%: 1.18-3.74)), foot (IRR: 1.70 (CI95%: 1.23-2.36)), humerus (IRR: 1.46 (CI95%: 1.04-2.05)), and tibia/fibula (IRR: 1.67 CI95%: 1.08-2.59)). In women with T1D, higher IRs were seen at the ankle (IRR: 2.25 (CI95%: 1.10-4.56)) and foot (IRR: 2.11 (CI95%: 1.27-3.50)), whereas in men with T1D, higher IRs were seen for carpal (IRR: 1.45 (CI95%: 1.14-1.86)), clavicle (IRR: 2.13 (CI95%: 1.13-4.02)), and humerus (IRR: 1.77 (CI95%: 1.10-2.83)) fractures.

conclusionThe incidence of carpal, clavicle, foot, humerus, and tibia/fibula fractures was higher in newly treated T1D, but there was no difference at other fracture sites compared to controls. Therefore, the higher incidence of fractures in newly treated people with T1D has been found mainly for distal fracture sites.

Indexed as

Diabetes Mellitus, Type 1Fractures, BoneFemaleHumansHumerusIncidenceMaleWrist JointFracture patternIncident fracturesType 1 diabetes

Identifiers

PMID34617151

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.