ReviewJVS-vascular science2021
Intraluminal thrombus: Innocent bystander or factor in abdominal aortic aneurysm pathogenesis?
Review in JVS-vascular science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 59 citations in OpenAlex.
- Preoperative D-dimer and Intraluminal Thrombus Ratio Appear to Interact in Predicting Aneurysm Expansion After Endovascular Repair in Patients With Persistent Type 2 Endoleak.Cardiovascular and interventional radiology · 2026Article
- Longitudinal 4D Flow MRI-Derived Wall Shear Stress in Patients With an Abdominal Aortic Aneurysm.Journal of magnetic resonance imaging : JMRI · 2026Article
- The role of neutrophils in the pathogenesis of abdominal aortic aneurysms.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Multimodal intra-subject characterization of abdominal aortic aneurysm pathophysiology: a case study.Biomechanics and modeling in mechanobiology · 2026Article
- Molecular and spatial heterogeneity of macrophage like vascular smooth muscle cells in abdominal aortic aneurysms associated with intraluminal thrombus.Scientific reports · 2026Article
- Thrombo-inflammation as a missing variable in thoracic aortic intervention timing: toward a biology-informed threshold.Frontiers in cardiovascular medicine · 2026Review
- Growth rate, diameter at rupture, and associated patient characteristics of abdominal aortic aneurysms without an intraluminal thrombus.JVS-vascular science · 2026Article
- Rethinking intraluminal thrombus in abdominal aortic aneurysm.JVS-vascular science · 2026Article
- Automated identification, hemodynamic visualisation and quantification of abdominal aortic aneurysms with 4D flow magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2026Article
- Complement and diverse enrichment of antibodies in intraluminal thrombi from abdominal aortic aneurysms may contribute to increased inflammation.Scientific reports · 2025Article
- Abdominal aortic aneurysm classification based on dynamic intraluminal thrombus analysis during cardiac cycle.Journal of vascular surgery cases and innovative techniques · 2025Article
- Sexual Dimorphism in Abdominal Aortic Aneurysm-Insights from Clinical and Experimental Studies.Journal of vascular diseases · 2025Article
- Nitric Oxide Distribution Correlates with Intraluminal Thrombus in Abdominal Aortic Aneurysm: A Computational Study.Bioengineering (Basel, Switzerland) · 2025Article
- Serum Creatinine Level in Relation to Intraluminal Thrombus and Abdominal Aortic Aneurysm Size.Journal of clinical medicine · 2025Article
- Hemodynamic predictors of rupture in abdominal aortic aneurysms: a case series using computational fluid dynamics.Frontiers in cardiovascular medicine · 2025Article
- Giant cavernous aneurysms occluded by aneurysmal thrombosis, calcification, parent artery occlusion: A case report and review of literature.World journal of clinical cases · 2024Article
- Current Prognostic Biomarkers for Abdominal Aortic Aneurysm: A Comprehensive Scoping Review of the Literature.Biomolecules · 2024Article
- Article
- Relative Thrombus Burden Ratio Reveals Overproportioned Intraluminal Thrombus Growth-Potential Implications for Abdominal Aortic Aneurysm.Journal of clinical medicine · 2024Article
- Implications of preoperative arterial stiffness for patients treated with endovascular repair of abdominal aortic aneurysms.JVS-vascular science · 2024Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbdominal aortic aneurysms (AAAs) represent a complex multifactorial hemodynamic, thrombotic, and inflammatory process that can ultimately result in aortic rupture and death. Despite improved screening and surgical management of AAAs, the mortality rates have remained high after rupture, and little progress has occurred in the development of nonoperative treatments. Intraluminal thrombus (ILT) is present in most AAAs and might be involved in AAA pathogenesis. The present review examined the latest clinical and experimental evidence for possible involvement of the ILT in AAA growth and rupture.
methodsA literature review was performed after a search of the PubMed database from 2012 to June 2020 using the terms "abdominal aortic aneurysm" and "intraluminal thrombus."
resultsThe structure, composition, and hemodynamics of ILT formation and propagation were reviewed in relation to the hemostatic and proteolytic factors favoring ILT deposition. The potential effects of the ILT on AAA wall degeneration and rupture, including a review of the current controversies regarding the position, thickness, and composition of ILT, are presented. Although initially potentially protective against increased wall stress, increasing evidence has shown that an increased volume and greater age of the ILT have direct detrimental effects on aortic wall integrity, which might predispose to an increased rupture risk.
conclusionsILT does not appear to be an innocent bystander in AAA pathophysiology. However, its exact role remains elusive and controversial. Despite computational evidence of a possible protective role of the ILT in reducing wall stress, increasing evidence has shown that the ILT promotes AAA wall degeneration in humans and in animal models. Further research, with large animal models and with more chronic ILT is crucial for a better understanding of the role of the ILT in AAAs and for the potential development of targeted therapies to slow or halt AAA progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.