Evidence map›Paper›PMID 34617062›Full record

ArticleJVS-vascular science2021

Transglutaminase 2 moderates the expansion of mouse abdominal aortic aneurysms.

Kathryn J Griffin, Kingsley R Simpson, Cora M L Beckers, Laura M Newell, Lih T Cheah, Nadira Y Yuldasheva, Siiri Iismaa, Christopher L Jackson, Julian D A Scott, Richard J Pease

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JVS-vascular science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Kathryn J GriffinLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Kingsley R SimpsonLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Cora M L BeckersLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Laura M NewellBristol Heart Institute, University of Bristol, Bristol, UK.
Lih T CheahLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Nadira Y YuldashevaLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Siiri IismaaVictor Chang Cardiac Research Institute, Darlinghurst, Australia.
Christopher L JacksonBristol Heart Institute, University of Bristol, Bristol, UK.
Julian D A ScottLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Richard J PeaseLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
University of Leeds · GBNIHR Bristol Cardiovascular Biomedical Research Unit · GBUniversity of Bristol · GBVictor Chang Cardiac Research Institute · AU

Funding

British Heart Foundation FS/11/91/29090British Heart Foundation PG/17/27/32928
6 · The paper itself

Abstract

objectivePreviously published work has indicated that transcripts encoding transglutaminase 2 (TG2) increase markedly in a rat model of abdominal aortic aneurysm. This study determines whether TG2 and the related TG, factor XIII-A (FXIII-A), protect against aortic aneurysm development in mice.

methodsC57BL/6J wild-type,

results

conclusionsKnockout of

Indexed as

AneurysmFactor XIII-ATransglutaminase 2

Identifiers

PMID34617062
PMCPMC8489235
OpenAlexW3163208266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.