Evidence map›Paper›PMID 34617043›Full record

ArticleJVS-vascular science2020

Adventitial matrix metalloproteinase production and distribution of immunoglobulin G4-related abdominal aortic aneurysms.

Satomi Kasashima, Atsuhiro Kawashima, Fuminori Kasashima, Yasushi Matsumoto, Yoshitaka Yamamoto, Satoru Ozaki, Hirofumi Takemura

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JVS-vascular science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Immunoglobulin G4-related solitary aneurysm of the deep femoral artery.Journal of vascular surgery cases and innovative techniques · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Satomi KasashimaDepartment of Clinical Laboratory Science, Graduate School of Health Science, Kanazawa University, Kanazawa, Japan.
Atsuhiro KawashimaDepartment of Pathology, National Hospital Organization, Kanazawa Medical Center, Kanazawa, Japan.
Fuminori KasashimaDepartment of Cardiovascular Surgery, National Hospital Organization, Kanazawa Medical Center, Kanazawa, Japan.
Yasushi MatsumotoDepartment of Cardiovascular Surgery, National Hospital Organization, Kanazawa Medical Center, Kanazawa, Japan.
Yoshitaka YamamotoDepartment of Cardiovascular Surgery, National Hospital Organization, Kanazawa Medical Center, Kanazawa, Japan.
Satoru OzakiDepartment of Clinical Laboratory Science, Graduate School of Health Science, Kanazawa University, Kanazawa, Japan.
Hirofumi TakemuraDepartment of Thoracic, Cardiovascular and General Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan.
Kanazawa Medical Center · JPKanazawa University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIgG4-related diseases are systemic inflammatory fibrous lesions characterized by elevated serum IgG4 and infiltration of IgG4-positive plasmacytes. They can manifest in vascular lesions as frequently formed aneurysms with prominent thickening of the adventitia (IgG4-related abdominal aortic aneurysm; IgG4-AAA). Matrix metalloproteinases (MMPs) degrade the extracellular matrix, mainly in the tunica media, resulting in destruction of aortic structures to cause enlargement of the aneurysm. However, the expression of adventitial MMPs in IgG4-AAAs is poorly understood.

methodsMMPs and MMPs-presenting cells in the adventitia of IgG4-AAAs (n = 19) of human surgical specimens were evaluated by immunohistochemistry and dual messenger RNA in situ hybridization. The results were compared with those from control groups of non-IgG4-related inflammatory AAA (n = 18), atherosclerotic AAA (aAAA; n = 11), and autopsy cases (n = 11). Preoperative serum MMPs levels of these groups were compared with the histologic data.

resultsExpression of MMP-9, MMP-2, and MMP-14 at the protein and messenger RNA levels in the adventitia was significantly higher in IgG4-AAAs than in controls. Other MMPs were scarce. The total number of MMP-9-positive cells was positively correlated with the diameter of the aneurysm (

conclusionsMMP-9 production in adventitial immune cells concerning lymphoid follicles was characteristic of IgG4-AAAs and might work in its activity with aneurysmal dilatation and adventitial thickening. Expressions of adventitial MMP-2 and MMP-14 were detected in histiocytes and fibroblasts outside lymphoid follicles, and were less concerned with the activity of IgG4-AAAs.

Indexed as

Adventitial thickeningArtery tertiary lymphoid organsFollicular dendritic cellsHistiocytesIgG4-related aortic aneurysmIgG4-related diseaseMatrix metalloproteinase

Identifiers

PMID34617043
PMCPMC8489202
OpenAlexW3042390136

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.