Evidence map›Paper›PMID 34617035›Full record

ArticleCritical care explorations2021

Respiratory Non-Invasive Venous Waveform Analysis for Assessment of Respiratory Distress in Coronavirus Disease 2019 Patients: An Observational Study.

Bret Alvis, Lexie Vaughn, Jeffrey Schmeckpeper, Jessica Huston, Marisa Case, Matthew Semler, JoAnn Lindenfeld, Colleen Brophy, Kyle Hocking

Open access · goldAbstract read
In one paragraph

Article in Critical care explorations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Bret AlvisDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN.
Lexie VaughnDepartment of Surgery, Vanderbilt University Medical Center, Nashville, TN.
Jeffrey SchmeckpeperDepartment of Medicine, Division of Cardiology, Heart Failure and Transplant, Vanderbilt University Medical Center, Nashville, TN.
Jessica HustonDepartment of Medicine, Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA.
Marisa CaseDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN.
Matthew SemlerDepartment of Medicine, Division of Allergy, Pulmonology, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN.
JoAnn LindenfeldDepartment of Medicine, Division of Cardiology, Heart Failure and Transplant, Vanderbilt University Medical Center, Nashville, TN.
Colleen BrophyVoluMetrix, LLC., Nashville, TN.
Kyle HockingDepartment of Biomedical Engineering, Vanderbilt University, Nashville, TN.
Vanderbilt University Medical Center · USUniversity of Pittsburgh Medical Center · USVanderbilt University · US

Funding

Non-Invasive Venous Waveform Analysis (NIVA) in patients with Heart Failure (HF)R44HL140669 · NHLBI · VOLUMETRIX, LLC · PI HOCKING, KYLE MITCHELL, LINDENFELD, JOANN · 2018 to 2025
$5.1M
Venous Waveform Analysis to Predict Volume OverloadR01HL148244 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Bret D. Alvis · 2019 to 2026
$3.4M
NHLBI NIH HHS R01 HL148244NHLBI NIH HHS R44 HL140669
6 · The paper itself

Abstract

objectivesDue to the rapid rate of severe acute respiratory syndrome coronavirus 2 transmission and the heterogeneity of symptoms of coronavirus disease 2019, expeditious and effective triage is critical for early treatment and effective allocation of hospital resources.

designA post hoc analysis of respiratory data from non-invasive venous waveform analysis among patients enrolled in an observational study was performed.

settingVanderbilt University Medical Center. PATIENTS: Peripheral venous waveforms were recorded from admission to discharge in enrolled coronavirus disease 2019-positive patients and healthy age-matched controls.

interventionsData were analyzed in LabChart 8 to transform venous waveforms to the frequency domain using fast Fourier transforms. The peak respiratory frequency was normalized to the peak cardiac frequency to generate a respiratory non-invasive venous waveform analysis respiratory index. Paired Fisher exact tests were used to compare each patient's respiratory non-invasive venous waveform analysis respiratory index at admission and discharge. A nonparametric one-way analysis of variance was used for multiple comparisons between patients with coronavirus disease 2019 and healthy controls for respiratory non-invasive venous waveform analysis respiratory index. MEASUREMENTS AND MAIN

resultsFifty coronavirus disease 2019-positive patients were enrolled between April 2020, and September 2020, and 45 were analyzed; 34 required supplemental oxygen and 11 did not. The respiratory non-invasive venous waveform analysis respiratory index was significantly higher for the 34 patients with coronavirus disease 2019 who received supplemental oxygen (median, 0.27; interquartile range, 0.11-1.28) compared with the 34 healthy controls (median, 0.06; interquartile range, 0.03-0.14) (

conclusionsRespiratory non-invasive venous waveform analysis respiratory index represents a novel physiologic respiratory measurement with a promising ability to triage early care and predict the need for oxygen support therapy in coronavirus disease 2019 patients.

Indexed as

coronaviruscoronavirus disease 2019non-invasive venous waveform analysissevere acute respiratory syndrome coronavirus 2

Identifiers

PMID34617035
PMCPMC8489896
OpenAlexW3202751586

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.