Evidence map›Paper›PMID 34617021›Full record

ArticleRadiology. Artificial intelligence2021

Accelerated Brain Aging in Amnestic Mild Cognitive Impairment: Relationships with Individual Cognitive Decline, Risk Factors for Alzheimer Disease, and Clinical Progression.

Weijie Huang, Xin Li, He Li, Wenxiao Wang, Kewei Chen, Kai Xu, Junying Zhang, Yaojing Chen, Dongfeng Wei, Ni Shu and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Artificial intelligence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 21 citations in OpenAlex.

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  9. A deep neural network estimation of brain age is sensitive to cognitive impairment and decline.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Weijie HuangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, P. R. China (W.H., X.L., H.L., W.W., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, Beijing, P. R. China (W.H., X.L., H.L., W.W., K.C., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, P. R. China (H.L., J.Z., D.W.); and Banner Alzheimer's Institute, Phoenix, Ariz (K.C.).
Xin LiState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, P. R. China (W.H., X.L., H.L., W.W., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, Beijing, P. R. China (W.H., X.L., H.L., W.W., K.C., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, P. R. China (H.L., J.Z., D.W.); and Banner Alzheimer's Institute, Phoenix, Ariz (K.C.).
He LiState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, P. R. China (W.H., X.L., H.L., W.W., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, Beijing, P. R. China (W.H., X.L., H.L., W.W., K.C., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, P. R. China (H.L., J.Z., D.W.); and Banner Alzheimer's Institute, Phoenix, Ariz (K.C.).
Wenxiao WangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, P. R. China (W.H., X.L., H.L., W.W., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, Beijing, P. R. China (W.H., X.L., H.L., W.W., K.C., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, P. R. China (H.L., J.Z., D.W.); and Banner Alzheimer's Institute, Phoenix, Ariz (K.C.).
Kewei ChenState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, P. R. China (W.H., X.L., H.L., W.W., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, Beijing, P. R. China (W.H., X.L., H.L., W.W., K.C., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, P. R. China (H.L., J.Z., D.W.); and Banner Alzheimer's Institute, Phoenix, Ariz (K.C.).ORCID 0000-0001-8497-3069
Kai XuState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, P. R. China (W.H., X.L., H.L., W.W., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, Beijing, P. R. China (W.H., X.L., H.L., W.W., K.C., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, P. R. China (H.L., J.Z., D.W.); and Banner Alzheimer's Institute, Phoenix, Ariz (K.C.).
Junying ZhangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, P. R. China (W.H., X.L., H.L., W.W., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, Beijing, P. R. China (W.H., X.L., H.L., W.W., K.C., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, P. R. China (H.L., J.Z., D.W.); and Banner Alzheimer's Institute, Phoenix, Ariz (K.C.).
Yaojing ChenState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, P. R. China (W.H., X.L., H.L., W.W., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, Beijing, P. R. China (W.H., X.L., H.L., W.W., K.C., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, P. R. China (H.L., J.Z., D.W.); and Banner Alzheimer's Institute, Phoenix, Ariz (K.C.).ORCID 0000-0003-4418-6890
Dongfeng WeiState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, P. R. China (W.H., X.L., H.L., W.W., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, Beijing, P. R. China (W.H., X.L., H.L., W.W., K.C., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, P. R. China (H.L., J.Z., D.W.); and Banner Alzheimer's Institute, Phoenix, Ariz (K.C.).
Ni ShuState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, P. R. China (W.H., X.L., H.L., W.W., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, Beijing, P. R. China (W.H., X.L., H.L., W.W., K.C., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, P. R. China (H.L., J.Z., D.W.); and Banner Alzheimer's Institute, Phoenix, Ariz (K.C.).ORCID 0000-0003-2420-2910
Zhanjun ZhangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, P. R. China (W.H., X.L., H.L., W.W., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Beijing Aging Brain Rejuvenation Initiative Centre, Beijing Normal University, Beijing, P. R. China (W.H., X.L., H.L., W.W., K.C., K.X., J.Z., Y.C., D.W., N.S., Z.Z.); Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, P. R. China (H.L., J.Z., D.W.); and Banner Alzheimer's Institute, Phoenix, Ariz (K.C.).ORCID 0000-0001-7266-4218
Beijing Normal University · CNAlzheimer's Association · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine whether a brain age prediction model could quantify individual deviations from a healthy brain-aging trajectory (predicted age difference [PAD]) in patients with amnestic mild cognitive impairment (aMCI) and to determine if PAD was associated with individual cognitive impairment. MATERIALS AND

methodsIn this retrospective study, a machine learning approach was trained to determine brain age based on T1-weighted MRI scans. Two datasets were used for model training and testing-the Beijing Aging Brain Rejuvenation Initiative (BABRI) (616 healthy controls and 80 patients with aMCI, 2010-2018) and the Alzheimer's Disease Neuroimaging Initiative (ADNI) (589 healthy controls and 144 patients with aMCI, 2010-2018). A total of 974 healthy controls were used for model training (490 from BABRI and 484 from ADNI; age range, 49-95 years). The trained model was then tested on both healthy controls (126 from BABRI and 105 from ADNI) and patients with aMCI (80 from BABRI and 144 from ADNI) to estimate PAD (predicted age - actual age). Furthermore, the associations between PAD with cognitive impairment, genetic risk factors and pathologic markers of Alzheimer disease (AD), and clinical progression in patients with aMCI were examined using a partial correlation analysis, a two-way analysis of covariance, and a general linear model, respectively.

resultsBased on the prediction model, patients with aMCI were found to have higher PADs than those of healthy controls (BABRI: 2.65 ± 4.91 [standard deviation] vs 0.18 ± 4.79 [

conclusionThe PAD is a sensitive imaging marker related to individual cognitive differences in patients with aMCI.

Indexed as

Brain AgeBrain/Brain StemMachine LearningMild Cognitive ImpairmentMR ImagingStructural MRI

Identifiers

PMID34617021
PMCPMC8489444
OpenAlexW3174673950

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.