Evidence map›Paper›PMID 34617007›Full record

ArticleJournal of the Canadian Association of Gastroenterology2021

Prevalence of Gastroduodenal Polyps in Children With Familial Adenomatous Polyposis.

James K Stone, Charles N Bernstein, Harminder Singh, Wael El-Matary

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Canadian Association of Gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

James K StoneDepartment of Internal Medicine, Section of Gastroenterology, University of Manitoba Max Rady College of Medicine, Winnipeg, Manitoba, Canada.
Charles N BernsteinDepartment of Internal Medicine, Section of Gastroenterology, University of Manitoba Max Rady College of Medicine, Winnipeg, Manitoba, Canada.ORCID https://orcid.org/0000-0001-8041-3574
Harminder SinghDepartment of Internal Medicine, Section of Gastroenterology, University of Manitoba Max Rady College of Medicine, Winnipeg, Manitoba, Canada.
Wael El-MataryDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.ORCID https://orcid.org/0000-0001-6417-7583
University of Manitoba · CACancerCare Manitoba · CAChildren's Hospital Research Institute of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the prevalence of upper gastrointestinal adenomatous polyps in a cohort of pediatric familial adenomatous polyposis (FAP) patients to determine if early screening is warranted. STUDY

designAll 11 pediatric FAP patients diagnosed in Manitoba between January 2012 and December 2019 were recruited. Patient records were examined and data on age of diagnosis, gene mutation, age of first screening endoscopy, number of endoscopies, number of gastric and colonic polyps, associated pathology, medications, symptoms and FAP-related surgeries were extracted and descriptive statistics reported.

resultsA total of 11 children were diagnosed with FAP over the study period with a mean age at diagnosis of 6.3 ± 3.2 years with 72.3% males and median follow-up of 4.8 years. The mean age at first gastroscopy was 10.9 ± 2.9 years and 10.8 ± 3.0 years at colonoscopy. Eight patients (72%) had upper gastrointestinal polyps, with adenomatous changes seen in seven of them on pathology. No patients had invasive carcinoma or high-grade dysplasia. All patients developed tubular adenomas on colorectal polyp pathology. Four (36%) patients underwent surgical colectomy.

conclusionsEarly-onset upper gastrointestinal adenomatous polyps in a pediatric FAP are common. Our study provides further data to support consideration of further, large-scale research into the benefit of early endoscopic screening for upper gastrointestinal malignancy in FAP patients.

Indexed as

Endoscopic screeningFAPGastric polypsPediatricTubular adenoma

Identifiers

PMID34617007
PMCPMC8489522
OpenAlexW3114568022

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.