Evidence map›Paper›PMID 34616758›Full record

ArticleFrontiers in medicine2021

A Systems-Level Analysis of Total-Body PET Data Reveals Complex Skeletal Metabolism Networks

Karla J Suchacki, Carlos J Alcaide-Corral, Samah Nimale, Mark G Macaskill, Roland H Stimson, Colin Farquharson, Tom C Freeman, Adriana A S Tavares

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Innate [European journal of nuclear medicine and molecular imaging · 2025
    Trial
  2. Network-Based Analysis for the Quantification of Brain and Body Immune Axes with Total-Body PET Imaging.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  3. Comparison of multi-organ CT image segmentation tools for whole-body [European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Digital Biopsy and Network Analysis of Dynamic [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Extracting value from total-body PET/CT image data - the emerging role of artificial intelligence.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
  9. Article
  10. Article
  11. Whole-Body PET Imaging: A Catalyst for Whole-Person Research?Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  12. Segmentation of Dynamic Total-Body [International journal of biomedical imaging · 2023
    Article
  13. Article
  14. Total-Body PET: Will It Change Science and Practice?Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Karla J SuchackiUniversity/British Heart Foundation (BHF) Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Carlos J Alcaide-CorralUniversity/British Heart Foundation (BHF) Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Samah NimaleUniversity/British Heart Foundation (BHF) Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Mark G MacaskillUniversity/British Heart Foundation (BHF) Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Roland H StimsonUniversity/British Heart Foundation (BHF) Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Colin FarquharsonThe Roslin Institute, The Royal (Dick) School of Veterinary Studies (RDSVS), Easter Bush Campus, University of Edinburgh, Edinburgh, United Kingdom.
Tom C FreemanThe Roslin Institute, The Royal (Dick) School of Veterinary Studies (RDSVS), Easter Bush Campus, University of Edinburgh, Edinburgh, United Kingdom.
Adriana A S TavaresUniversity/British Heart Foundation (BHF) Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
British Heart Foundation · GBThe Queen's Medical Research Institute · GBUniversity of Edinburgh · GBRoslin Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/R/00003741Medical Research Council MR/S035761/1Wellcome Trust
6 · The paper itself

Abstract

Bone is now regarded to be a key regulator of a number of metabolic processes, in addition to the regulation of mineral metabolism. However, our understanding of complex bone metabolic interactions at a systems level remains rudimentary.

Indexed as

bonemetabolismnetwork analysispositron emission tomographysystem biology

Identifiers

PMID34616758
PMCPMC8488174
OpenAlexW3198960423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.