Evidence map›Paper›PMID 34616753›Full record

ArticleFrontiers in medicine2021

Primary Hyperoxaluria Type 1 Disease Manifestations and Healthcare Utilization: A Multi-Country, Online, Chart Review Study.

Xiangling Wang, David Danese, Thomas Brown, Jessica Baldwin, Gautam Sajeev, Erin E Cook, Yao Wang, Chunyi Xu, Hongbo Yang, Michael L Moritz

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Final Results of the ILLUMINATE-A Phase 3 Clinical Trial of Lumasiran for Primary Hyperoxaluria 1.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Trial
  2. Article
  3. Hyperoxaluria: Diagnosis and Treatment.The Urologic clinics of North America · 2025
    Review
  4. [Biological characteristics of liver zonation and its role in disease and aging].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
  5. Review
  6. Article
  7. Observational
  8. Distinct hepatocyte identities in liver homeostasis and regeneration.JHEP reports : innovation in hepatology · 2023
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Xiangling WangCenter for Personalized Genetic Healthcare, Department of Nephrology and Hypertension, Department of Molecular Medicine, Cleveland Clinic, Cleveland, OH, United States.
David DaneseAlnylam Pharmaceuticals, Inc., Cambridge, MA, United States.
Thomas BrownAlnylam Pharmaceuticals, Inc., Cambridge, MA, United States.
Jessica BaldwinAlnylam Pharmaceuticals, Inc., Cambridge, MA, United States.
Gautam SajeevAnalysis Group, Inc., Boston, MA, United States.
Erin E CookAnalysis Group, Inc., Boston, MA, United States.
Yao WangAnalysis Group, Inc., Boston, MA, United States.
Chunyi XuAnalysis Group, Inc., Boston, MA, United States.
Hongbo YangAnalysis Group, Inc., Boston, MA, United States.
Michael L MoritzDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Analysis Group (United States) · USAlnylam Pharmaceuticals (United States) · USCleveland Clinic · USUniversity of Pittsburgh · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

chart reviewchronic kidney diseasehealthcare resource utilizationkidney stonesoxaluriaprimary hyperoxaluria type 1urinary tract infections

Identifiers

PMID34616753
PMCPMC8488346
OpenAlexW3200561142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.