Evidence map›Paper›PMID 34616570›Full record

ArticleCardiology research and practice2021

The Dose-Dependent Effects of Spironolactone on TGF-

Mirong Tang, Yan Chen, Fuqing Sun, Liangliang Yan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiology research and practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mirong TangDepartment of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou City 350001, China.ORCID https://orcid.org/0000-0002-5522-8825
Yan ChenDepartment of Ultrasound,Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou City 350001, China.ORCID https://orcid.org/0000-0003-2609-1505
Fuqing SunDepartment of Interventional Catheter Room, Department of Cardiovascular, Fuqing Municipal Hospital, Fuqing Municipal Hospital Affiliated to Fujian Medical University, Fuzhou City 350300, China.ORCID https://orcid.org/0000-0001-5021-729X
Liangliang YanDepartment of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou City 350001, China.ORCID https://orcid.org/0000-0003-4438-0925
Fujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study tends to assess the dose-dependent effects of spironolactone on TGF-

methodsForty 20-week-old male SHRs were randomly divided into 4 groups (10 rats per group): 3 spironolactone groups were lower-dose group (10 mg·kg

resultsCompared with group C, the myocardial cell size, atrial fibrosis, TGF-

conclusionHypertension can lead to cardiomyocyte hypertrophy, deposition of interstitial fibrosis in myocardial tissue, and an increase in the vulnerability to atrial fibrillation. Spironolactone showed a certain dose-dependent effect in SHRs. Lower-dose spironolactone was superior to higher-dose spironolactone in the aspect of reducing hypertensive atrial fibrosis and TGF-

Identifiers

PMID34616570
PMCPMC8490048
OpenAlexW3203724318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.